JSM 2016 Online Program

Sessions Were Renumbered as of May 19.

Legend:
CC-W = McCormick Place Convention Center, West Building,   CC-N = McCormick Place Convention Center, North Building
H = Hilton Chicago,   UC= Conference Chicago at University Center
* = applied session       ! = JSM meeting theme

Activity Details

213714	Fri, 7/1/2016, 2:00 PM - 3:30 PM	H-McCormick Boardroom
Committee on Applied Statisticians Meeting — Other Cmte/Business
Committee on Applied Statisticians
Chair(s): Erin Tanenbaum, NORC at the University of Chicago

6 *	Sun, 7/31/2016, 2:00 PM - 3:50 PM	CC-W184bc
Open Source Statistical Software for Data Science — Invited Papers
Journal of Statistical Software , Section for Statistical Programmers and Analysts , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee
Organizer(s): John Emerson, Yale University
Chair(s): Christopher Fonnesbeck, Vanderbilt University
2:05 PM	Software Engineering for Data Science — Skipper Seabold, Civis Analytics
2:25 PM	The Python Data Science Stack — Jake VanderPlas, University of Washington
2:45 PM	Flexibility and Speed: Can We Have Both? — Douglas Bates, University of Wisconsin
3:05 PM	If You Can't Beat 'Em . — Dirk Eddelbuettel, Ketchum Trading/Debian & R Projects
3:25 PM	Grammars and Structures for Computing with Data — Michael Kane, Yale University
3:45 PM	Floor Discussion

7 * !	Sun, 7/31/2016, 2:00 PM - 3:50 PM	CC-W179a
Statistical Learning of Health Care Systems — Invited Papers
Health Policy Statistics Section , Committee on Applied Statisticians
Organizer(s): Ying Lu, Palo Alto VA Health Care System/Stanford University
Chair(s): Ying Lu, Palo Alto VA Health Care System/Stanford University
2:05 PM	Two Case Studies of Statistical Approaches That Simplify the VHA Learning Health Care System — Rebecca B. McNeil, Durham VA Medical Center ; Kellie J. Sims, Durham VA Medical Center ; Leah L. Zullig, Durham VA Medical Center ; George L. Jackson, Durham VA Medical Center ; Dawn T. Provenzale, Durham VA Medical Center
2:30 PM	An Overview of Innovative Statistical Designs for Point-of-Care Comparative Effectiveness Trials — Mei-Chiung Shih, Palo Alto VA Health Care System/Stanford University
2:55 PM	Model Fitting with Distributed Data — Balasubramanian Narasimhan Narasimhan, Stanford University
3:40 PM	Floor Discussion

8 * !	Sun, 7/31/2016, 2:00 PM - 3:50 PM	CC-W190b
Issues in Predictive Biomarker in Oncology Drug Development — Invited Papers
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Peipei Shi, Biogen
Chair(s): Peipei Shi, Biogen
2:05 PM	Issues in Biomarker-Based Oncology Trial Design — Daniel Sargent, Mayo Clinic
2:25 PM	Accuracy Measures for Predictive Biomarkers — Richard Macey Simon, National Cancer Institute
2:45 PM	Adjusting for Enrichment Effects When Estimating Oncology Biomarker Clinical Utility — Jared Lunceford, Merck Research Laboratories
3:05 PM	Bias in Lifetime Data Analysis for Validation of Biomarkers — Tinghui Yu, FDA/CDRH ; Yabing Mai, Merck Research Laboratories
3:25 PM	Discussant: Gene Pennello, FDA/CDRH/OSB/DBS
3:45 PM	Floor Discussion

15 *	Sun, 7/31/2016, 2:00 PM - 3:50 PM	CC-W196a
Recent Advances in Early Phase I/II Cancer Trials Using Drug Combinations — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Mourad Tighiouart, Cedars-Sinai Medical Center
Chair(s): Ying Yuan, MD Anderson Cancer Center
2:05 PM	The Utility of Conditional Autoregressive (CAR) Models for Modeling Efficacy of Molecularly Targeted Agents in Early-Phase Trials — Thomas Braun, University of Michigan
2:25 PM	Two-Stage Design for Phase I/II Cancer Clinical Trials Using Drug Combinations of Cytotoxic Agents — Mourad Tighiouart, Cedars-Sinai Medical Center ; Quanlin Li
2:45 PM	Early-Phase Design for a Combination of Immunotherapies — Nolan Wages, University of Virginia ; Craig Slingluff, University of Virginia ; Gina Petroni, University of Virginia
3:05 PM	Discussant: Andre Rogatko, Cedars-Sinai Medical Center
3:25 PM	Floor Discussion

17 * !	Sun, 7/31/2016, 2:00 PM - 3:50 PM	CC-W194b
Missing Data in Neuroscience Clinical Trials: Truth or Consequences — Topic Contributed Papers
Mental Health Statistics Section , ENAR , Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Pilar Lim, Janssen R&D
Chair(s): Hsien-Ming James Hung, FDA
2:05 PM	Choosing Estimands in Clinical Trials with Missing Data — Craig Mallinckrodt, Eli Lilly and Company
2:25 PM	Reference-Based Imputation Versus Dropout = Failure Imputation for Tackling Missing Data — Devan V. Mehrotra, Merck ; Fang Liu, Merck
2:45 PM	Role of Simulations in the Selection of the Primary Estimand and Statistical Methods for Handling Missing Data — Elena Polverejan, Janssen R&D
3:05 PM	Discussant: Scott Emerson, University of Washington
3:25 PM	Floor Discussion

50 * !	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W178a
Statistical Challenges and Power in Integrating Big and Complex Imaging Data — Invited Papers
SSC , Section on Statistics in Imaging , Royal Statistical Society , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Linglong Kong, University of Alberta
Chair(s): Linglong Kong, University of Alberta
4:05 PM	Estimation and Inference for Brain Connectivity Analysis — Lexin Li, University of California at Berkeley
4:30 PM	PDEs and Regularized Principal Component Analysis of Functional Connectivity Maps — Eardi Lila, University of Cambridge ; John Aston, University of Cambridge ; Laura Sangalli, Politecnico di Milano
4:55 PM	An Autologistic Regression Model for Binary Classification of Hyperspectral Remote Sensing Imagery — Charmaine Dean, University of Western Ontario ; Mark Wolters, Fudan University
5:20 PM	Functional Connectivity for Prediction and Classification: Characterization and Estimation — DuBois Bowman, Columbia University
5:35 PM	Floor Discussion

54 *	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W183c
Recent Advances in Information Visualization — Invited Papers
Section on Statistical Graphics , Committee on Applied Statisticians
Organizer(s): Yihui Xie, RStudio
Chair(s): Carlos E. Scheidegger, University of Arizona
4:05 PM	Using Maximum Topology Matching to Explore Differences in Species Distribution Models — Jorge Poco, University of Washington
4:25 PM	Automatic Selection of Partitioning Variables for Small Multiple Displays — Anushka Anand, Tableau Research
4:45 PM	Visualizing Statistical Mix Effects and Simpson's Paradox — Zan Armstrong, Freelance Data Visualization
5:05 PM	ImMens: Real-Time Visual Querying of Big Data — Zhicheng Liu, Adobe Research
5:25 PM	An Algebraic Process for Visualization Design — Gordon Kindlmann, The University of Chicago
5:45 PM	Floor Discussion

60 * !	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W187a
Power of Blinded Data Reviews — Topic Contributed Papers
Section on Statistical Consulting , Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Ibrahim Turkoz, Janssen R&D
Chair(s): Ibrahim Turkoz, Janssen R&D
4:05 PM	Predicting the Timing of the Final Event in a Clinical Trial Using the Bayesian Bootstrap and Beyond — Marc Sobel, Temple University ; Ibrahim Turkoz, Janssen R&D
4:25 PM	Control Charts for Monitoring Accumulating Adverse Event Count Frequencies from Single and Multiple Blinded Trials — A. Gould, Merck Research Laboratories
4:45 PM	Continuous Event Monitoring via a Bayesian Predictive Approach — Jianing Di, Janssen R&D ; Daniel Wang, Janssen R&D ; Robert Brashear, Janssen R&D ; Vlad Dragalin, Janssen ; Michael Krams, Janssen R&D
5:05 PM	Enrollment and Event Prediction for Blinded Clinical Trials — Hrishikesh Kulkarni, Cytel ; Yannis Jemiai, Cytel
5:25 PM	Discussant: Sue-Jane Wang, FDA
5:45 PM	Floor Discussion

63 * !	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W193b
New Developments on Network Meta-Analysis in Clinical Trials — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Cindy Lu, Bayer HealthCare Pharmaceuticals
Chair(s): Jerry Weaver, Celgene
4:05 PM	On the Sensitivity Analysis for Bayesian Network Meta-Analysis — Haoda Fu
4:25 PM	Network Meta-Analysis for Ordinal Outcomes: An Application in Comparing Crohn's Disease Treatments — May Mo, Amgen ; Yeongjin Gwon, University of Connecticut ; Ming-Hui Chen, University of Connecticut ; Amy Xia, Amgen ; Juan Li, Amgen ; Joseph G. Ibrahim, The University of North Carolina at Chapel Hill
4:45 PM	Incorporation of Individual Patient Data in Network Meta-Analysis for Multiple Continuous Endpoints, with Application to Diabetes Treatment — Hwanhee Hong, Johns Hopkins Bloomberg School of Public Health ; Haoda Fu ; Karen Price, Eli Lilly and Company ; Bradley Carlin, University of Minnesota
5:05 PM	Network Meta-Analysis for Missing Binary Outcomes from Part of the Network — Cindy Lu, Bayer HealthCare Pharmaceuticals ; Robert Wan, AstraZeneca
5:25 PM	Use of Informative Prior Information in Network Meta-Analysis of Rare Adverse Events — David Ohlssen, Novartis
5:45 PM	Floor Discussion

65 * !	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W192b
Synthesizing Evidence from Different Sources for Robust Decision Making in Cancer Clinical Trials — Topic Contributed Papers
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Suddhasatta Acharyya, Novartis
Chair(s): Sofia Paul, Novartis
4:05 PM	Combining Safety and Efficacy Data for Assessing Risk Benefit in Cancer Clinical Trials: Some Recent Examples — Thomas Kelleher, Bristol-Myers Squibb
4:25 PM	Inference for Time-to-Event Endpoints in Combined Populations Under Disproportionate Stratified Sampling — Jyotirmoy Dey, AbbVie ; Wuyan Zhang, Pfizer
4:45 PM	Using Meta-Analysis in the Design and Analysis of Early-Phase Cancer Studies — Ashok Panneerselvam, Novartis Oncology ; Sofia Paul, Novartis ; Suddhasatta Acharyya, Novartis
5:05 PM	Regulatory Challenges in Evidence Synthesis in Cancer Clinical Trials — Rajeshwari Sirdhara, FDA
5:25 PM	Discussant: Amit Bhattacharyya, GlaxoSmithKline
5:45 AM	Floor Discussion

85	Sun, 7/31/2016, 4:00 PM - 5:50 PM	CC-W176a
Administrative Records and Data Disclosure — Contributed Papers
Government Statistics Section , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Chair(s): Jiashen You, Department of Transportation
4:05 PM	Implementation and Results of a New Administrative Record-Linkage Methodology in the Quarterly Census of Employment and Wages — Jessica Helfand, Bureau of Labor Statistics ; Justin McIllece, Bureau of Labor Statistics
4:20 PM	Documenting and Resolving the Discrepancy in Government Estimates of the Size and Legal Composition of the U.S. Foreign-Born Population — Guillermina Jasso, New York University ; Mark R. Rosenzweig, Yale University
4:35 PM	Survey Respondents' Perceptions on Data Confidentiality and Data Sharing — Jacob Bournazian, U.S. Energy Information Administration
4:50 PM	ReASSESS: A Robust Adaptive Mechanism Using Subsetting and Multiplicative Weights in Data Synthesis — Evercita Cuevas Eugenio, University of Notre Dame ; Fang Liu, University of Notre Dame
5:05 PM	Visualizing Mortality Differences in Rural Health — Erin Tanenbaum, NORC at the University of Chicago ; Alana Knudson, NORC at the University of Chicago ; Marilyn Klug, University of North Dakota ; Michael Meit, NORC at the University of Chicago ; Joanne Brady, NORC at the University of Chicago ; Tess Gilbert, NORC at the University of Chicago ; Emily Arsen, NORC at the University of Chicago
5:20 PM	An Ordering that Improves the Cell Suppression Pattern in Sequential Processing — Bei Wang, U.S. Census Bureau
5:35 PM	Reproducibility Promotes Transparency, Efficiency, and Aesthetics — Richard Schwinn, U.S. Small Business Administration

102 * !	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W179a
Advances in Bayesian Regression Tree Modeling — Invited Papers
Section on Bayesian Statistical Science , Section on Nonparametric Statistics , International Society for Bayesian Analysis (ISBA) , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee
Organizer(s): Matthew Pratola, The Ohio State University
Chair(s): Matthew Pratola, The Ohio State University
8:35 AM	BART for Classification — Robert B. Gramacy, The University of Chicago
9:00 AM	Dispersion Modeling with an Ensemble of Trees — Hugh Chipman, Acadia University ; Matthew Pratola, The Ohio State University ; Robert McCulloch, The University of Chicago ; Edward I. George, The Wharton School
9:25 AM	Nonparametric Regression with Instrumental Variables — Purushottam Laud, Medical College of Wisconsin ; Robert McCulloch, The University of Chicago ; Rodney Sparapani, Medical College of Wisconsin
9:50 AM	Bayesian Additive Regression Trees: Extensions and Embedding in Complex Models — Jared S. Murray, Carnegie Mellon University
10:15 AM	Floor Discussion

106 * !	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W196b
Applied Data Visualization in Industry and Journalism — Invited Papers
Section on Statistical Graphics , Royal Statistical Society , Section for Statistical Programmers and Analysts , Committee on Applied Statisticians , Statistics Without Borders
Organizer(s): Hilary Parker, Stitch Fix
Chair(s): Hilary Parker, Stitch Fix
8:35 AM	Linked Brushing in R — Hadley Wickham, Rice University
8:55 AM	Creating Data Visualization Tools at Facebook — Andreas Gros, Facebook
9:15 AM	Cocktail Party Horror Stories About Data Vis for Clients — Lynn Cherny, Ghostweather R&D
9:35 AM	Visualizing the News at FiveThirtyEight — Andrei Scheinkman, FiveThirtyEight.com
9:55 AM	Teaching Data Visualization to 100k Data Scientists: Lessons from Evidence-Based Data Analysis — Jeffrey Leek, Johns Hopkins Bloomberg School of Public Health
10:15 AM	Floor Discussion

107 * !	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W184bc
Joint Modeling of Survival Time with Another Outcome in Clinical Trials or Observation Studies — Invited Papers
Biometrics Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Tianle Hu, Eli Lilly and Company
Chair(s): Tianle Hu, Eli Lilly and Company
8:35 AM	Bayesian Joint Modeling of Longitudinal and Survival Data with Treatment Switches — Fan Zhang, University of Connecticut ; Ming-Hui Chen, University of Connecticut ; Qingxia Chen, Vanderbilt University ; Xiuyu Julie Cong, Boehringer Ingelheim Pharmaceuticals
9:00 AM	Joint Modeling of Survival Time and Longitudinal Outcomes with Flexible Random Effects — Jianwen Cai, The University of North Carolina at Chapel Hill ; Jaeun Choi, Albert Einstein College of Medicine ; Donglin Zeng, The University of North Carolina at Chapel Hill ; Andy Olshan, The University of North Carolina at Chapel Hill
9:25 AM	Joint Modeling of Survival Time with Another Outcome in Clinical Trials or Observational Studies — Ross L. Prentice, Fred Hutchinson Cancer Research Center ; Shanshan Zhao, National Institute of Environmental Health Sciences
9:50 AM	Analysis of Proportional Hazards Model with Sparse Longitudinal Covariates — Jason Fine, The University of North Carolina at Chapel Hill
10:15 AM	Floor Discussion

108 * !	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W194b
Inference of Network Structures — Invited Papers
Committee on Applied Statisticians
Organizer(s): Dabao Zhang, Purdue University
Chair(s): Dabao Zhang, Purdue University
8:35 AM	Measuring Influence of Users in Twitter Ecosystems Using a Counting Process Modeling Framework — Donggeng Xia, University of Michigan ; George Michailidis, University of Florida ; Shawn Mankad, Cornell University
9:05 AM	A Two-Stage Method for Genome-Wide Gene Regulatory Network Construction — Chen Chen, Purdue University ; Min Zhang, Purdue University ; Dabao Zhang, Purdue University
9:35 AM	Theoretic, Algorithmic, and Empirical Issues in the Application of Directed Probabilistic Graphical Models for Network Inference When Analyzing Genomics Data — Jason Mezey, Cornell University
10:05 AM	Floor Discussion

113 *	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W185bc
Challenges in Design and Analysis of Multi-Regional Clinical Trials — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Gang Li, Johnson & Johnson
Chair(s): Gang Li, Johnson & Johnson
8:35 AM	MRCT Design Models and Drop-Min Data Analysis — Kuang-Kuo Lan, Janssen R&D
8:55 AM	Design and Analysis of Multiregional Clinical Trials in Evaluation of Medical Devices: Some Points to Consider from a Regional Regulatory Perspective — Yunling Xu, FDA/CDRH ; Nelson LU, FDA/CDRH
9:15 AM	Why Can't We Agree on MRCTs? — Joshua Chen, Sanofi Pasteur
9:35 AM	Example-Based Illustrations of Design, Conduct, Analysis, and Result Interpretation of Multi-Regional Clinical Trials — Hui Quan, Sanofi ; Xuezhou Mao, Sanofi
9:55 AM	Discussant: Hsien-Ming James Hung, FDA
10:15 AM	Floor Discussion

118 *	Mon, 8/1/2016, 8:30 AM - 10:20 AM	CC-W185d
Challenges in Metagenomic Data Analysis: Reproducibility and Interpretability of Inferences on Microbial Community Composition and Dynamics — Topic Contributed Papers
Section on Statistics in Genomics and Genetics , Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Hector Corrada Bravo, University of Maryland
Chair(s): Jianxin Shi, National Cancer Institute
8:35 AM	Dimensional Reduction of Metagenomic Data with Ecological Equivalence — Senthilkumar Muthiah, University of Maryland ; Eric Slud, U.S. Census Bureau ; Mihai Pop, University of Maryland ; Hector Corrada Bravo, University of Maryland
8:55 AM	Multivariate Dimension-Reduction Methods for Microbiome Data Analysis — Kim-Anh Le Cao, University of Queensland
9:15 AM	Mediation Analysis of High-Dimensional Human Microbiome Data in the Longitudinal Study — Huilin Li , New York University Langone Medical Center ; Yilong Zhang, New York University ; Martin J. Blaser, New York University
9:35 AM	Floor Discussion

141 * !	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W180
Some New Perspectives in Statistical Analysis with Incomplete Data — Invited Papers
SSC , Committee on Applied Statisticians , Statistics Without Borders
Organizer(s): Peisong Han, University of Waterloo
Chair(s): Peisong Han, University of Waterloo
10:35 AM	A Note on Multiple Imputation Under Informative Sampling — Jae-kwang Kim, Iowa State University ; Shu Yang, Harvard
11:00 AM	Weighted Estimating Equations for Semiparametric Transformation Models with Missing Covariates — Grace Yi, University of Waterloo ; Yang Ning ; Nancy Reid, University of Toronto
11:25 AM	On the Problem of Bias and Variance Amplification of the Instrumental Calibration Estimator in the Presence of Unit Nonresponse — David Haziza, Université de Montréal ; Éric Lesage, INSEE ; Xavier D'Haultfoeuille, CREST/ENSAE
11:50 AM	Discussant: Jae-kwang Kim, Iowa State University
12:10 PM	Floor Discussion

144 * !	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W184bc
Choosing Appropriate Estimands in Clinical Trials — Invited Papers
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Frank Bretz, Novartis Pharma
Chair(s): Estelle Russek-Cohen, FDA
10:35 AM	Estimands: Are We Estimating What We Intend to Estimate? — Mouna Akacha , Novartis Pharma AG
11:00 AM	Some Observations on De Jure Estimation — Thomas Permutt, FDA
11:25 AM	The Treatment of Missing Data in a Large Cardiovascular Clinical Outcomes Study — Roderick Joseph Little, University of Michigan
11:50 AM	Discussant: Gary Koch, The University of North Carolina at Chapel Hill
12:10 PM	Floor Discussion

145 *	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W196a
Integrating Evidence for Better Health Care and Policy Decisions — Invited Papers
Health Policy Statistics Section , Committee on Applied Statisticians
Organizer(s): Laura Anne Hatfield, Harvard Medical School
Chair(s): Laura Anne Hatfield, Harvard Medical School
10:35 AM	Tailoring Decision Making to Reflect Patient Preferences and Expected Treatment Outcomes — Megan S. Schuler, Harvard Medical School ; Laura Anne Hatfield, Harvard Medical School
11:00 AM	Hierarchical Regression and Variance-Function Modeling to Estimate the Inter-Rater Intraclass Correlation Coefficient in Assessments of Shared Decision Making — James O'Malley, Geisel School of Medicine at Dartmouth ; Paul J. Barr, Geisel School of Medicine at Dartmouth ; Glyn Elwyn, Geisel School of Medicine at Dartmouth
11:25 AM	Integrating Patient Voice and Experience in Benefit and Risk Assessments — Laura Lee Johnson, FDA
11:50 AM	Discussant: Arlene Ash, University of Massachusetts Medical School
12:10 PM	Floor Discussion

149 * !	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W190a
Recent Advances and Challenges of Big Data Inference with Complex Structures — Invited Papers
International Chinese Statistical Association , Royal Statistical Society , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee
Organizer(s): Zhao Ren, University of Pittsburgh
Chair(s): Zhao Ren, University of Pittsburgh
10:35 AM	Statistical Inference for High-Dimensional Linear Regression — Tony Cai, University of Pennsylvania ; Zijian Guo, University of Pennsylvania
11:00 AM	Distributed Estimation and Inference with Statistical Guarantees — Heather Battey, Imperial College London ; Jianqing Fan, Princeton ; Han Liu, Princeton ; Junwei Lu, Princeton ; Ziwei Zhu, Princeton
11:25 AM	Phase Transitions in Semidefinite Programming and Graph Estimation — Andrea Montanari, Stanford University
11:50 AM	A General Framework for Bayes Structured Linear Models — Harrison Zhou, Yale University ; Chao Gao, Yale University
12:15 PM	Floor Discussion

151 * !	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W183c
Benefit-Risk Evaluation in Medicine — Invited Papers
Section on Medical Devices and Diagnostics , International Chinese Statistical Association , Committee on Applied Statisticians , Section on Risk Analysis
Organizer(s): Martin Ho, FDA/CDRH
Chair(s): Norberto Pantoja-Galicia, FDA/CDRH
10:35 AM	An Overview of Structured Benefit-Risk Analysis — Qi Jiang, Amgen ; Weili He, Merck
11:00 AM	Bayesian Benefit Risk Assessments for Medical Products — Telba Irony, FDA
11:25 AM	Recent Developments in Benefit-Risk Evaluation for Diagnostic Tests — Gene Pennello, FDA/CDRH/OSB/DBS ; Norberto Pantoja-Galicia, FDA/CDRH ; Scott Evans, Harvard
11:50 AM	Discussant: Scott Evans, Harvard
12:10 PM	Floor Discussion

154 * !	Mon, 8/1/2016, 10:30 AM - 12:20 PM	CC-W192b
Adaptive Design in Large-Scale Sample Surveys: Different Perspectives — Invited Panel
Social Statistics Section , Committee on Applied Statisticians , Statistics Without Borders
Organizer(s): Marilyn Seastrom, National Center for Education Statistics
Chair(s): Brian Harris-Kojetin, Committee on National Statistics
10:35 AM	Adaptive Design in Large-Scale Sample Surveys: Different Perspectives
Panelists:	Peter Miller, U.S. Census Bureau Marilyn Seastrom, National Center for Education Statistics Paul Biemer, RTI International
12:15 PM	Floor Discussion

222 * !	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W185d
Tricks and Treats in Classification and Regression Trees — Invited Papers
Section on Statistical Computing , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Wei-Yin Loh, University of Wisconsin
Chair(s): Wenwen Zhang, Takeda
2:05 PM	Overcoming Computational Challenges of Subgroup Identification Using SIDES Method — Ilya Lipkovich, Quintiles ; Alex Dmitrienko, Quintiles
2:30 PM	Smooth Sigmoid Surrogate (SSS): An Alternative to Greedy Search in Recursive Partitioning — Xiaogang Su, The University of Texas at El Paso ; Joseph Kang, CDC ; Lei Liu, Northwestern University ; Qiong Yang, Boston University ; Juanjuan Fan, San Diego State University ; Richard Levine, San Diego State University
2:55 PM	Some Ideas Left Out of CART — Padraic Grantier Neville, SAS Institute
3:20 PM	Some Tricks Behind the GUIDE Algorithm — Wei-Yin Loh, University of Wisconsin
3:45 PM	Floor Discussion

225 * !	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W178b
The Power of Efficient Sampling Designs for Studies of Correlated Endpoints — Invited Papers
Section on Statistics in Epidemiology , Committee on Applied Statisticians
Organizer(s): Paul Rathouz, University of Wisconsin - Madison
Chair(s): Paul Rathouz, University of Wisconsin - Madison
2:05 PM	Sparse Opportunistic Sampling in Population Pharmacokinetic Studies — William H. Fissell, Vanderbilt University ; Pratish Patel, Vanderbilt University ; Matthew S. Shotwell, Vanderbilt University
2:30 PM	On the Analysis of Case-Control and Stratified Case-Control Studies in Cluster-Correlated Data Settings — Sebastien Haneuse, Harvard T.H. Chan School of Public Health ; Claudia Rivera, Harvard T.H. Chan School of Public Health
2:55 PM	Auxiliary Variable Sampling Designs for Longitudinal Binary Data with Application to Spirometry-Based COPD Diagnosis — Jonathan Scott Schildcrout, Vanderbilt University
3:20 PM	Efficient Subsampling of Expensive-to-Evaluate Longitudinal Outcomes — John Neuhaus, University of California at San Francisco ; Charles McCulloch, University of California at San Francisco
3:45 PM	Floor Discussion

228 * !	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W183c
The Extraordinary Power of Statistical Collaboration — Invited Papers
Section on Statistical Consulting , International Chinese Statistical Association , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Organizer(s): Eric Vance, Laboratory for Interdisciplinary Statistical Analysis
Chair(s): Doug Zahn, Florida State University
2:05 PM	Moving from Statistical Consulting to Collaboration — Kim Love, K. R. Love Quantitative Consulting and Collaboration
2:30 PM	The Extraordinary Power of Statistical Collaboration in Industry — LeAnna Stork, Monsanto
2:55 PM	The Power of Statistical Collaboration in Government — Carol Gotway Crawford, USDA/NASS
3:20 PM	The Extraordinary Potential of Statistical Collaboration Laboratories — Eric Vance, Laboratory for Interdisciplinary Statistical Analysis
3:45 PM	Floor Discussion

231 * !	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W193a
Application of Novel Methods in Clinical Trials: Case Study Approaches — Topic Contributed Papers
Biometrics Section , Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Arkendu S. Chatterjee, Novartis
Chair(s): Soumi Lahiri, GlaxoSmithKline
2:05 PM	Some New Metrics to Test for Biosimilarity — Sujit K. Ghosh, North Carolina State University ; Yifang Li, Novartis
2:25 PM	BOIN: A Simple, Ethical Bayesian Optimal Design for Phase I Oncology Trials — Ying Yuan, MD Anderson Cancer Center ; Suyu Liu, MD Anderson Cancer Center
2:45 PM	Early-Phase Designs for Targeted and Immunotherapeutic Agents — Codruta Chiuzan, Columbia University
3:05 PM	Using Surrogate Marker Information to Test for a Treatment Effect — Layla Parast, RAND Corporation ; Tianxi Cai, Harvard ; Lu Tian, Stanford University
3:25 PM	A Note on Posterior Predictive Assessment to Assess Model Fit — Arkendu S. Chatterjee, Novartis ; Dandan Xu, University of Florida ; Michael Daniels, The University of Texas at Austin
3:45 PM	Floor Discussion

236 * !	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W176b
Multiple Imputation -- Multiple Challenges — Topic Contributed Papers
Survey Research Methods Section , Committee on Applied Statisticians
Organizer(s): Florian Meinfelder, Otto-Friedrich-Universität Bamberg
Chair(s): Trivellore Raghunathan, University of Michigan
2:05 PM	Benchmarking and Assessment for Multiple Imputation — Gerko Vink, Utrecht University
2:25 PM	Interactions and Squares: Don't Transform, Just Impute! — Philipp Gaffert, GfK SE ; Volker Bosch, GfK SE ; Florian Meinfelder, Otto-Friedrich-Universität Bamberg
2:45 PM	Optimal Split Questionnaire Survey Design in the Longitudinal Setting — Paul Michael Imbriano, University of Michigan ; Trivellore Raghunathan, University of Michigan
3:05 PM	Optimal Missing-by-Design Patterns with Genetic Algorithms — Florian Meinfelder, Otto-Friedrich-Universität Bamberg ; Sara Bahrami, Leibniz Institute for Educational Trajectories
3:25 PM	Discussant: Susanne Rässler, Otto-Friedrich-Universität Bamberg
3:45 PM	Floor Discussion

237 *	Mon, 8/1/2016, 2:00 PM - 3:50 PM	CC-W196a
Quantitative Sciences for Safety Monitoring and Confirmatory Safety in Clinical Development — Topic Contributed Papers
Biopharmaceutical Section , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Organizer(s): Judy X. Li, FDA
Chair(s): Qi Jiang, Amgen
2:05 PM	ASA Biopharm's Safety Monitoring Subteam: Survey of Statisticians, Thought Leaders, and Regulatory Guidance — Mike Wright Colopy, UCB Bioscience ; Susan Duke, AbbVie
2:25 PM	Safety-Monitoring Methodology in the Premarketing Setting — Melvin Munsaka, Takeda Development Center
2:45 PM	Statistical Considerations for Cardiovascular Outcome Trials in Patients with T2DM — Maria Matilde Sanchez-Kam, Arena Pharmaceuticals
3:05 PM	Discussant: William Wang, Merck
3:25 PM	Discussant: Ram Tiwari, FDA/CDER/OT/OB
3:45 PM	Floor Discussion

213638	Mon, 8/1/2016, 5:00 PM - 6:30 PM	H-4L
Social Mixer for Applied Statisticians — Other Cmte/Business
Committee on Applied Statisticians
Chair(s): Erin Tanenbaum, NORC at the University of Chicago

282 *	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W180
Bayesian Methods for Complex Networks — Invited Papers
Section on Bayesian Statistical Science , International Society for Bayesian Analysis (ISBA) , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Francesco Stingo, MD Anderson Cancer Center
Chair(s): Francesco Stingo, MD Anderson Cancer Center
8:35 AM	Decouple/Recouple: Dynamic Graphical Modeling and Time Series Forecasting — Mike West, Duke University ; Lutz Gruber, QuantCo
9:05 AM	A Bayesian Framework for Modeling Human Mobility — Adrian Dobra, University of Washington
9:35 AM	Bayesian Multiplicity Control for Multiple Graphs — Peter Mueller, The University of Texas at Austin ; Riten Mitra, University of Louisville ; Yuan Ji, NorthShore University HealthSystem
10:05 AM	Floor Discussion

290 * !	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W185bc
What to Do with Messy Data? Four Case Studies — Invited Papers
Section for Statistical Programmers and Analysts , International Chinese Statistical Association , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee , Statistics in Business Schools Interest Group
Organizer(s): Taylor B. Arnold
Chair(s): Taylor B. Arnold
8:35 AM	A Changepoint Model for Housing Values — Xiaofei Susan Wang, Yale University ; John Emerson, Yale University
9:00 AM	From Sports to Real Estate: Real-World Data Facts of Life — John Emerson, Yale University
9:25 AM	Two Approaches to Topic Modeling Within an Encyclopedic Corpus — Lauren Tilton, Yale University
9:50 AM	Floor Discussion

300 * !	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W196c
Recent Advancement of Statistical Methods and Tools for Go/No-Go Decision Making — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Qi Tang, AbbVie
Chair(s): Deli Wang, AbbVie
8:35 AM	Comparison of Various Early-Phase Go/No Go Decision Criteria — Yili Pritchett, MedImmune ; Masanori Ito, Astellas Pharma
8:55 AM	Using Little 'Go' Decisions — Scott Berry, Berry Consultants
9:15 AM	Interim Go/No-Go Decision Making in Clinical Trials with Longitudinal Outcomes — Ming Zhou, Bristol-Myers Squibb ; Qi Tang, AbbVie ; Lixin Lang, Bristol-Myers Squibb ; Jun Xing, Bristol-Myers Squibb ; Kay Tatsuoka, Bristol-Myers Squibb
9:35 AM	Statistical Software for Decision Making in Clinical Development — Charles Liu, Cytel ; Yannis Jemiai, Cytel
9:55 AM	Enhancing the Probability of Success Framework for Go/No-Go Decision Making Using ROC Curves — Alan Hartford, AbbVie ; Qi Tang, AbbVie ; Deli Wang, AbbVie ; Jyotirmoy Dey, AbbVie ; Walt Offen, AbbVie ; Frank Shen, AbbVie
10:15 AM	Floor Discussion

304 *	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W195
Innovative Bayesian Applications in Drug Development — Topic Contributed Papers
Biopharmaceutical Section , International Society for Bayesian Analysis (ISBA) , Section on Bayesian Statistical Science , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Fanni Natanegara, Eli Lilly and Company
Chair(s): JonDavid Sparks, Eli Lilly and Company
8:35 AM	Bayesian Framework in Small Sample Trials — Freda Cooner, FDA/CDER/OTS/OB/DB2
8:55 AM	Innovative Bayesian Applications in Clinical Trials — Soumi Lahiri, GlaxoSmithKline ; Satrajit Roychoudhury, Novartis
9:15 AM	Bayesian Predictive Approach to Concurrent Tailoring of Phase 3 Clinical Trials Intended for Registration — Ming-Dauh Wang, Eli Lilly and Company ; Aijun Gao, inVentiv Health ; Jinghui Liu, inVentiv Health ; Karen Price, Eli Lilly and Company ; MaryAnn Morgan-Cox, Eli Lilly and Company ; Lei Shen, Eli Lilly and Company
9:35 AM	Bayesian Assurance and Sample-Size Determination in the Process Validation Lifecycle — Paul Faya, Baylor University ; John W. Seaman, Jr., Baylor University ; James D. Stamey, Baylor University
9:55 AM	Discussant: Fanni Natanegara, Eli Lilly and Company
10:15 AM	Floor Discussion

305 * !	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W183a
A Roadmap for Promoting Statistical Collaboration — Topic Contributed Panel
Section on Statistical Consulting , Quality and Productivity Section , Section on Physical and Engineering Sciences , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee
Organizer(s): Erin Tanenbaum, NORC at the University of Chicago
Chair(s): Eric Vance, Laboratory for Interdisciplinary Statistical Analysis
8:35 AM	A Roadmap for Promoting Statistical Collaboration
Panelists:	Robin Mogg, Merck Research Laboratories Chuck Kincaid, Experis Holly Shulman, CDC Mark Otto, Fish and Wildlife Service
10:15 AM	Floor Discussion

310 *	Tue, 8/2/2016, 8:30 AM - 10:20 AM	CC-W184a
Improvements in Quality Assurance and Statistical Process Control — Contributed Papers
Quality and Productivity Section , Committee on Applied Statisticians
Chair(s): Erin Tanenbaum, NORC at the University of Chicago
8:35 AM	Sample Size Study for Measurement Systems Analysis Models — Laura Lancaster, SAS Institute ; Chris Gotwalt, SAS Institute
8:50 AM	Control Chart Based on Quasi-Likelihood Estimation for Monitoring Profiles — Chung-I Li
9:05 AM	Effects of Standard Deviation Estimation on the X-Bar Control Chart and Adjustments for a Guaranteed In-Control Performance — Felipe Jardim, Pontífice Universidade Católica Rio de Janeiro ; Subhabrata Chakraborti, University of Alabama ; Eugenio Epprecht, Pontífice Universidade Católica Rio de Janeiro
9:20 AM	Operating Characteristic Curves for K-Factors of Normal Tolerance Intervals — Derek Young, University of Kentucky
9:35 AM	The Power of Statistics to Reduce Manufacturing Costs: Optimal Inspection Interval for a Finite Population — Elizabeth Kelly, Los Alamos National Laboratory
9:50 AM	Comparing Binomial and Scan Statistics Methods in QC — Chunrong Cheng, FDA ; Boguang Zhen, FDA
10:05 AM	An Improved Method for Constructing an Upper Confidence Limit for Proportion of Nonconformance in Normal Processes — Yanling Zuo, Minitab

343 *	Tue, 8/2/2016, 10:30 AM - 12:20 PM	CC-W194b
Novel Missing Data Imputation Methods — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Freda Cooner, FDA/CDER/OTS/OB/DB2
Chair(s): John Scott, FDA
10:35 AM	Two Approaches for Conducting Control-Based Imputation in Handling Missing Data — Guanghan Liu, Merck Research Laboratories
10:55 AM	Making Use of the Predictive Distribution for Missing Data — Gerry Gray, FDA/CDRH
11:15 AM	Novel Missing Data Imputation Methods — Peter Mesenbrink, Novartis Pharma
11:35 AM	Novel Imputation Methods for Binary, Time-to-Event, and Recurrent-Event Outcomes — Michael O'Kelly, Quintiles
11:55 AM	Discussant: Feng Li, FDA/CDER/OTS/OB/DB2
12:15 PM	Floor Discussion

346 *	Tue, 8/2/2016, 10:30 AM - 12:20 PM	CC-W196a
Summarizing Case Studies to Learn from and Improve Adaptive Trial Design and Implementation — Topic Contributed Papers
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Weili He, Merck
Chair(s): Weili He, Merck
10:35 AM	Highpoints of What We Learned from Case Studies of Less Well-Understood Adaptively Designed Trials — Eva Miller, InVentiv Health Clinical
10:55 AM	Case Study: How Promising Is the VALOR Trial for the Future of Adaptive Designs? — Yannis Jemiai, Cytel
11:15 AM	Regulatory and Practical Considerations for an Adaptive Trial in the Context of Evaluating a Combination Product: An Example Using Two Human MAbs to Prevent Recurrence of CDI — Kenneth Koury, Merck Research Laboratories ; Robert Tipping, Merck Research Laboratories
11:35 AM	Discussant: Jerry Schindler, Merck
11:55 AM	Discussant: Gregory Levin, FDA
12:15 PM	Floor Discussion

347 * !	Tue, 8/2/2016, 10:30 AM - 12:20 PM	CC-W192b
Advances in Statistical Methods for Systems Biology — Topic Contributed Papers
Section on Statistics in Genomics and Genetics , Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Li Ma, Duke University
Chair(s): Barbara E. Engelhardt, Princeton
10:35 AM	A Big Table for Gene Regulatory Analysis — Wing Hung Wong, Stanford University
10:55 AM	Statistical Models for Single Cell RNA RNA Analysis — Nancy Zhang, University of Pennsylvania ; Cheng Jia, University of Pennsylvania ; Yuchao Jiang, University of Pennsylvania ; Mingyao Li, University of Pennsylvania
11:15 AM	A Bayesian Nonparametric Analysis of Heterogeneous Data on Microbial Communities — Sergio Bacallado
11:35 AM	Analysis of Distributional Variation: A Multi-Resolution Scanning Approach with Applications to DNase-Seq Analysis — Li Ma, Duke University
11:55 AM	Bayesian Nonparametric Multiple Testing for the Analysis of Microbiome Data — Michele Guindani
12:15 PM	Floor Discussion

348 * !	Tue, 8/2/2016, 10:30 AM - 12:20 PM	CC-W192a
Statistical Methodology to Address Challenges in Medical Diagnostic Devices — Topic Contributed Papers
Section on Medical Devices and Diagnostics , Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Jeng Mah, Beckman Coulter Inc.
Chair(s): Alvin Van Orden, FDA
10:35 AM	A Bayesian Adaptive Clinical Trial Design: Diagnostic Accuracy of an Olfactory Diagnostic Test for Traumatic Brain Injury in Combat Soldiers — Benjamin Saville, Berry Consultants
10:55 AM	The Effects on Diagnostic Accuracy of Repeated Testing and Decision Rule Design — Jeng Mah, Beckman Coulter Inc.
11:15 AM	Group Sequential Method for Correlated ROC Curves — Xuan Ye, FDA ; Larry Tang, George Mason University
11:35 AM	Method Comparison Study for Diagnostic Devices with Dichotomous Output — Bipasa Biswas, FDA/CDRH
11:55 AM	Floor Discussion

360 * !	Tue, 8/2/2016, 10:30 AM - 12:20 PM	CC-W179b
Consulting, Collaboration, Communication, and Impact — Contributed Papers
Section on Statistical Consulting , Committee on Applied Statisticians , Statistics Without Borders
Chair(s): James Grady, University of Connecticut Health Center
10:35 AM	Initiating the Uninitiated to Remote Statistical Collaboration: How Can Statistical Consultants Help Clients to Become Effective Remote Collaborators? — Linda A. Landon, Research Communiqué
10:50 AM	Characteristics of Biostatistics, Epidemiology, and Research Design Programs in Institutions with Clinical and Translational Science Awards — Mohammad H. Rahbar, The University of Texas Health Science Center at Houston ; Aisha S. Dickerson, The University of Texas Health Science Center at Houston ; Chul Ahn, The University of Southwestern Medical Center at Dallas ; Rickey E. Carter, Mayo Clinic ; Manouchehr Hessabi, The University of Texas Health Science Center at Houston ; Christopher J. Lindsell, University of Cincinnati ; Paul J. Nietert, Medical University of South Carolina ; Robert A. Oster, University of Alabama at Birmingham ; Brad H. Pollock, University of California at Davis ; Leah J. Welty, Northwestern University
11:05 AM	LISA 2020: Improving Agricultural Research in Tanzania Through Statistical Collaboration — Richard Ngaya, Virginia Tech ; Eric Vance, Laboratory for Interdisciplinary Statistical Analysis
11:20 AM	The Importance of Problem Definition in Statistical Consulting: An Illustration Using Academic Undermatching — Jillian Downey, Iowa State University ; Ulrike Genschel, Iowa State University ; Ann Gansemer-Topf, Iowa State University ; Mark Kaiser, Iowa State University
11:35 AM	Ethical Reasoning with the 2016 Revised ASA Ethical Guidelines for Statistical Practice — Nilupa Gunaratna, Harvard T.H. Chan School of Public Health
11:50 AM	Effective Collaboration Between Biostatisticians with Clinicians in Conducting Medical Research: Results Reporting — Yahya Daoud, Baylor Scott & White Health ; Sophie Lopes, Baylor Scott & White Health
12:05 PM	When Is 'Wrong' Really Right and Other Consulting Adventures — Katherine Monti, Rho

407 *	Tue, 8/2/2016, 2:00 PM - 3:50 PM	CC-W179a
Interactive Visualizations and Web Applications for Analytics — Invited Papers
Section on Statistical Graphics , Section on Statistics in Imaging , Committee on Applied Statisticians , Conference on Statistical Practice Steering Committee , Statistics Without Borders
Organizer(s): Ramnath Vaidyanathan, Alteryx
Chair(s): Heike Hofmann, Iowa State University
2:05 PM	Radiant: A Platform-Independent Browser-Based Interface for Business Analytics in R — Vincent Nijs, Rady School of Management
2:20 PM	Rbokeh: An R Interface to the Bokeh Plotting Library — Ryan Hafen, Hafen Consulting
2:35 PM	Composable Linked Interactive Visualizations in R with Htmlwidgets and Shiny — Joseph Cheng, RStudio
2:50 PM	Papayar: A Better Interactive Neuroimage Plotter in R — John Muschelli, The Johns Hopkins University
3:05 PM	Interactive and Dynamic Web-Based Graphics for Data Analysis — Carson Sievert, Iowa State University
3:20 PM	HTML Widgets: Interactive Visualizations from R Made Easy! — Yihui Xie, RStudio ; Ramnath Vaidyanathan, Alteryx
3:35 PM	Floor Discussion

422 * !	Tue, 8/2/2016, 2:00 PM - 3:50 PM	CC-W194b
Methodological and Practical Aspects of Adaptive Model-Based Design of Clinical Trials — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Sergei Leonov, ICON Clinical Research
Chair(s): Sergei Leonov, ICON Clinical Research
2:05 PM	Practical Experiences with Adaptive Dose-Escalation Designs in Early-Phase Oncology Trials — Inna Perevozskaya, Pfizer
2:25 PM	Application of Adaptive Designs to Optimize a Compound Development Program — Yevgen Tymofyeyev, J & J PRD
2:45 PM	Interim Timing in Adaptive Two-Stage Dose-Finding Studies: What Happens to the Expected Benefit? — Tobias Mielke, ICON PLC
3:05 PM	Discussant: William Rosenberger, George Mason University
3:25 PM	Discussant: Cristiana Mayer, Janssen R&D
3:45 PM	Floor Discussion

465 * !	Wed, 8/3/2016, 8:30 AM - 10:20 AM	CC-W192a
Data Science for Health Policy: A Broad Tent — Invited Papers
Health Policy Statistics Section , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Organizer(s): Sherri Rose, Harvard Medical School
Chair(s): Sherri Rose, Harvard Medical School
8:35 AM	What Works in Boston May Not Work in Los Angeles: A Double Robust Transportability Estimator for Understanding Site Differences in Policy Interventions — Kara Rudolph, University of California at Berkeley ; Mark van der Laan, University of California at Berkeley
9:00 AM	Identifying the Most Harmful Sources of Ambient Air Pollution to Better Protect Public Health — Jenna Krall, Emory University
9:25 AM	Generating Policy-Relevant Statistical Evidence in Sequentially Monitored Vaccine and Drug Safety Evaluations Using Electronic Health Record Data — Jennifer Clark Nelson, Group Health Research Institute ; Andrea J. Cook , Group Health Research Institute ; Robert Wellman, Group Health Research Institute ; Ram Tiwari, FDA/CDER/OT/OB ; Michael Nguyen, FDA ; Estelle Russek-Cohen, FDA ; Tracey Marsh, University of Washington ; Azadeh Shoaibi, FDA ; Denise Boudreau, Group Health Research Institute
9:50 AM	Assessing Causal Impacts of Policy in the HIV Care Cascade — Joseph Hogan, Brown University
10:15 AM	Floor Discussion

473 *	Wed, 8/3/2016, 8:30 AM - 10:20 AM	CC-W178a
Subgroups Analyses: Planned Versus Ad-Hoc: How Many Are Too Many? — Invited Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Vipin Arora, Eli Lilly and Company
Chair(s): Lisa LaVange, Office of Biostatistics Organization
8:35 AM	Subgroup Analyses in Early-Phase Clinical Trials: Challenges and Opportunities — Björn Bornkamp, Novartis ; Marius Thomas, Novartis
8:55 AM	Visualizing the Limitations of Subgroup Analyses — Kevin Andrew Buhr, University of Wisconsin - Madison
9:15 AM	Subgroup Analysis in Regulatory Decision Making — Lilly Yue, FDA/CDRH/OSB
9:35 AM	Visualization vs traditional presentation of data - what is there in subgroups? — Vipin Arora, Eli Lilly and Company
9:55 AM	Discussant: Judith D. Goldberg, New York University School of Medicine
10:15 AM	Floor Discussion

476 * !	Wed, 8/3/2016, 8:30 AM - 10:20 AM	CC-W183a
'With Great Power Comes Great Responsibility': Harnessing the Extraordinary Power of Statistics — Invited Panel
Section on Statistical Consulting , Committee on Applied Statisticians , Statistics in Business Schools Interest Group , Statistics Without Borders
Organizer(s): Michiko I. Wolcott, Msight Analytics
Chair(s): Michiko I. Wolcott, Msight Analytics
8:35 AM	'With Great Power Comes Great Responsibility': Harnessing the Extraordinary Power of Statistics
Panelists:	Susan E. Spruill, Applied Statistics and Consulting Daniel H. Mowrey, Eli Lilly and Company/Elanco Walter Stroup, University of Nebraska - Lincoln Jonathan Potts, Scoring Solutions
10:15 AM	Floor Discussion

477 * !	Wed, 8/3/2016, 8:30 AM - 10:20 AM	CC-W176c
Extraordinary Power of Remote Collaboration and Team Science — Invited Panel
WNAR , Royal Statistical Society , International Chinese Statistical Association , Caucus for Women in Statistics , Committee on Applied Statisticians , Statistics Without Borders
Organizer(s): Amanda Golbeck, University of Montana, Motomi Mori, Oregon Health & Science University
Chair(s): Amanda Golbeck, University of Montana
8:35 AM	Extraordinary Power of Remote Collaboration and Team Science
Panelists:	Motomi Mori, Oregon Health & Science University Mimi Kim, Albert Einstein College of Medicine Antje Hoering, Cancer Research and Biostatistics William Sollecito, The University of North Carolina at Chapel Hill Brisa N. Sanchez, University of Michigan
10:15 AM	Floor Discussion

481 * !	Wed, 8/3/2016, 8:30 AM - 10:20 AM	CC-W179a
Small Clinical Trials: Challenging Traditional Thinking — Topic Contributed Papers
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians
Organizer(s): Satrajit Roychoudhury, Novartis
Chair(s): Satrajit Roychoudhury, Novartis
8:35 AM	Impact of Adaptive Design on Optimization of Pharmaceutical Portfolios — Zoran Antonijevic
8:55 AM	Maximizing the Efficiency of Proof-of-Concept Studies and of Arrays of Proof-of-Concept Studies for Multiple Drugs or Indications — Robert Beckman, Georgetown University Medical Center
9:15 AM	Challenges and Experience in Designing Small Clinical Trials — Christopher Coffey, University of Iowa
9:35 AM	An Extrapolation Framework to Specify Requirements for Drug Development in Children — Gerald Hlavin, Medical University of Vienna ; Franz Koenig, Medical University of Vienna ; Christoph Male, Medical University of Vienna ; Martin Posch, Medical University of Vienna ; Peter Bauer, Medical University of Vienna
9:55 AM	Discussant: Pandurang Kulkarni, Eli Lilly and Company
10:15 AM	Floor Discussion

213702	Wed, 8/3/2016, 10:30 AM - 12:00 PM	CC-N227a
Implementing Successful Chapter and Section Mentoring Programs — Other Cmte/Business
Committee on Applied Statisticians , Mentoring Award Committee
Organizer(s): Amarjot Kaur, Merck, Mark Otto, Fish and Wildlife Service

517 * !	Wed, 8/3/2016, 10:30 AM - 12:20 PM	CC-W181a
Do Courts Appreciate the Power of Statistical Evidence? — Invited Papers
Royal Statistical Society , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians , Statistics Without Borders
Organizer(s): Joseph L. Gastwirth, The George Washington University
Chair(s): Joseph L. Gastwirth, The George Washington University
10:35 AM	Detecting and Correcting Publication Bias in Legal Cases — Edward K. Cheng, Vanderbilt University
11:00 AM	Recent Statistical Issues in U.S. Courts — Qing Pan, The George Washington University ; Joseph L. Gastwirth, The George Washington University ; Weiwen Miao, Haverford College
11:25 AM	The Misuse of Statistical Evidence in Tort Law — Claire McIvor, University of Birmingham, UK
11:50 AM	Expert Evidence for Civil Cases in Australia, England, Scotland, Northern Ireland, USA, and South Africa: Examples and Ethical Challenges — Jane Luise Hutton, University of Warwick
12:15 PM	Floor Discussion

529 * !	Wed, 8/3/2016, 10:30 AM - 12:20 PM	CC-W190b
Using Statistics to Understand Health Care Quality: New Methods and Applications — Topic Contributed Papers
Health Policy Statistics Section , Biopharmaceutical Section , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Organizer(s): Amelia M. Haviland, Carnegie Mellon University
Chair(s): Maria Cuellar, Carnegie Mellon University
10:35 AM	Varying Relationships Between Beneficiary Traits and Quality Measures Affect Comparisons in Medicare Advantage — Laura Anne Hatfield, Harvard Medical School ; Alan M. Zaslavsky, Harvard Medical School
10:55 AM	Insurance Premiums and Patient Experience: Do You Get What You Pay for in Medicare Advantage Plans? — Amelia M. Haviland, Carnegie Mellon University ; Sai MA, Centers for Medicare and Medicaid Services ; Katrin Hambarsoomian, RAND Corporation ; Marc N. Elliott, RAND Corporation
11:15 AM	Extension to the Bayesian Improved Surname Geocoding (BISG) Method — Marc N. Elliott, RAND Corporation ; Amelia M. Haviland, Carnegie Mellon University ; Ann Haas, RAND Corporation ; John Adams, Kaiser Permanente ; Joshua Mallet, RAND Corporation ; Jake Dembosky, RAND Corporation ; Sarah Gaillot, Centers for Medicare and Medicaid Services ; Samuel "Chris" Haffer, Centers for Medicare and Medicaid Services
11:35 AM	Methodological Considerations When Adjusting Quality Measures for Socioeconomic Status — Susan M. Paddock, RAND Corporation ; Melony E. Sorbero, RAND Corporation ; Cheryl L. Damberg, RAND Corporation ; Ann Haas, RAND Corporation ; Marc N. Elliott, RAND Corporation
11:55 AM	Discussant: John Adams, Kaiser Permanente
12:15 PM	Floor Discussion

530 *	Wed, 8/3/2016, 10:30 AM - 12:20 PM	CC-W187a
The Promise and Perils of External Patient-Level Data: Applications in Drug Development — Topic Contributed Papers
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): Greg Hather, Takeda
Chair(s): Ray Liu, Takeda
10:35 AM	Leveraging Individual Patient Data Meta-Analysis to Support a Go or No-Go Decision — Alan Chiang, Eli Lilly and Company ; Ann Cleverly, Eli Lilly and Company
10:55 AM	Boosting the Power of Phase II and III Oncology Studies Using Project Data Sphere — Greg Hather, Takeda ; Ray Liu, Takeda
11:15 AM	Facilitating Clinical Trial Simulation in Alzheimer's Disease Using the CAMD IPD, Literature Summary Level Data, and the 'adsim' R Package — Daniel Polhamus, Metrum Research Group
11:35 AM	Using External Patient Data in Clinical Trial Simulation — Forrest Williamson, Eli Lilly and Company
11:55 AM	Discussant: Jeffry Florian, FDA/CDER
12:15 PM	Floor Discussion

535 * !	Wed, 8/3/2016, 10:30 AM - 12:20 PM	CC-W183a
Global Challenges and Collaboration in Biopharmaceutical Statistics — Topic Contributed Panel
Biopharmaceutical Section , International Chinese Statistical Association , Committee on Applied Statisticians , Statistics Without Borders , Committee on International Relations in Statistics
Organizer(s): Toshimitsu Hamasaki, National Cerebral and Cardiovascular Center
Chair(s): Geert Molenberghs, Universiteit Hasselt
10:35 AM	Global Challenges and Collaboration in Biopharmaceutical Statistics
Panelists:	Jose Pinheiro, Johnson & Johnson Yuki Ando, Pharmaceutical and Medical Device Agency, Japan Frank Bretz, Novartis Pharma Estelle Russek-Cohen, FDA Abdus S. Wahed, University of Pittsburgh

579 * !	Wed, 8/3/2016, 2:00 PM - 3:50 PM	CC-W183a
Challenges and Opportunities for Analysis of High-Dimensional and Big Data — Invited Papers
ENAR , Committee on Applied Statisticians
Organizer(s): Kevin He, University of Michigan
Chair(s): Kevin He, University of Michigan
2:05 PM	CoCoLasso for High-Dimensional Error-in-Variables Regression — Hui Zou, University of Minnesota ; Abhirup Datta, University of Minnesota
2:30 PM	Covariance-Insured Screening Methods for Ultrahigh-Dimensional Variable Selection — Yi Li, University of Michigan ; Ji Zhu, University of Michigan ; Jiashun Jin, Carnegie Mellon University ; Kevin He, University of Michigan ; Yanming Li, University of Michigan
2:55 PM	Robust Covariance Estimation for Approximate Factor Models — Jianqing Fan, Princeton ; Weichen Wang, Princeton ; Yiqiao Zhong, Princeton
3:20 PM	Discussant: Jiashun Jin, Carnegie Mellon University
3:40 PM	Floor Discussion

586 * !	Wed, 8/3/2016, 2:00 PM - 3:50 PM	CC-W196c
Collaboration Among Academia, Industry, and Government, and the Role of ASA — Invited Papers
Committee on ASA Archives and Historical Materials , International Chinese Statistical Association , Scientific and Public Affairs Advisory Committee , Committee on Applied Statisticians
Organizer(s): Mahinda Karunaratne, AbbVie
Chair(s): Mahinda Karunaratne, AbbVie
2:05 PM	Case Studies in Academic-Industry-Government Collaborations in Bayesian Adaptive Clinical Trials — Bradley Carlin, University of Minnesota
2:30 PM	An Academic on the Factory Floor: My Experience as the David Jordan Visiting Scholar — Rick Chappell, University of Wisconsin - Madison
2:55 PM	The Whole Is Greater Than the Sum of Its Parts: ASA Members Working Together — Wendy Martinez, Bureau of Labor Statistics ; Anna Nevius
3:20 PM	Discussant: Frank Harrell, Vanderbilt University School of Medicine
3:45 PM	Floor Discussion

596 *	Wed, 8/3/2016, 2:00 PM - 3:50 PM	CC-W185d
Statistical Challenges in Drug Development in the Era of Immuno-Oncology — Topic Contributed Papers
Biopharmaceutical Section , Section on Statistical Consulting , Committee on Applied Statisticians
Organizer(s): Ji Lin, Eli Lilly and Company
Chair(s): Jingyi Liu, Eli Lilly and Company
2:05 PM	How Many Birds Can Be Killed with One Stone? The KEYNOTE-001 Experience — Cong Chen, Merck ; Nicole Li, Merck ; Jin Zhang, Merck
2:25 PM	Measures of Clinical Benefit in Immuno-Oncology Studies — Luping Zhao ; Pralay Mukhopadhyay, AstraZeneca
2:45 PM	Generalized Pairwise Comparisons for Several Complex Outcome Measures — Marc Buyse
3:05 PM	Combination Studies with Immuno-Oncology Drugs — Jonathan Denne, Eli Lilly and Company ; Yanping Wang, Eli Lilly and Company
3:25 PM	Improved Designs and Analyses of Safety and Efficacy in Immuno-Oncology — Bo Huang, Pfizer ; Margarida Geraldes, Pfizer
3:45 PM	Floor Discussion

597 *	Wed, 8/3/2016, 2:00 PM - 3:50 PM	CC-W185bc
Emerging Topics in Benefit-Risk Assessment in Clinical Development Decision Making — Topic Contributed Papers
Biopharmaceutical Section , Committee on Applied Statisticians , Section on Risk Analysis
Organizer(s): Weili He, Merck
Chair(s): Jonathan Norton, MedImmune
2:05 PM	Practical Considerations for Benefit Risk Assessment and Implementation: Vorapaxar TRA-2P TIMI 50 Case Study — Weili He, Merck
2:25 PM	Patient Preference in Benefit-Risk Analysis in Medical Device Trials — Xuefeng Li, FDA
2:45 PM	Benefit-Risk Assessment via Case Studies — George Quartey, Genentech ; Qi Jiang, Amgen ; Weili He, Merck
3:05 PM	Some Consideration on Endpoint Selection, Weighting Determination, and Uncertainty Evaluation in the Benefit-Risk Assessment in Pharmaceutical Drug Development — Haijun Ma ; Qi Jiang, Amgen
3:25 PM	Discussant: Martin Ho, FDA/CDRH
3:45 PM	Floor Discussion

635 * !	Thu, 8/4/2016, 8:30 AM - 10:20 AM	CC-W190b
Combining Data from Multiple Sources: Examples from Health Policy — Invited Papers
Health Policy Statistics Section , Committee on Applied Statisticians
Organizer(s): Juned Siddique, Northwestern University
Chair(s): Elizabeth Stuart, Johns Hopkins Bloomberg School of Public Health
8:35 AM	Combining Information from Two Data Sources with Misreporting and Incompleteness to Assess Hospice-Use Among Cancer Patients: A Multiple Imputation Approach — Yulei He, CDC ; Mary-Beth Landrum, Harvard Medical School ; Alan M. Zaslavsky, Harvard Medical School
9:00 AM	Correcting for Measurement Error in Self-Reported Dietary Data from a Longitudinal Lifestyle Intervention Trial Using an External Validation Study — Juned Siddique, Northwestern University ; Laurence Freedman, Gertner Institute for Epidemiology and Health Policy Research ; Raymond Carroll, Texas A&M University ; Trivellore Raghunathan, University of Michigan ; Elizabeth Stuart, Johns Hopkins Bloomberg School of Public Health
9:25 AM	Combining Item Response Theory with Multiple Imputation to Equate Health Assessment Questionnaires — Chenyang Gu, Brown University ; Roee Gutman, Brown University ; Vincent Mor, Brown University
9:50 AM	Discussant: Ofer Harel, University of Connecticut
10:10 AM	Floor Discussion

637 * !	Thu, 8/4/2016, 8:30 AM - 10:20 AM	CC-W176c
My Life as a Statistical Consultant — Invited Panel
Section on Statistical Consulting , Section for Statistical Programmers and Analysts , Committee on Applied Statisticians
Organizer(s): Xiaoyue Niu, Penn State University
Chair(s): Xiaoyue Niu, Penn State University
8:35 AM	My Life as a Statistical Consultant
Panelists:	James Rosenberger, Penn State University Mary Batcher, Ernst and Young Nathaniel Schenker, CDC/NCHS
10:10 AM	Floor Discussion

648 *	Thu, 8/4/2016, 8:30 AM - 10:20 AM	CC-W183a
Outside the Closed Door: Industry Statisticians Discuss the DMC Process — Topic Contributed Panel
Biopharmaceutical Section , Committee on Applied Statisticians
Organizer(s): David Kerr, Axio Research
Chair(s): David Kerr, Axio Research
8:35 AM	Outside the Closed Door: Industry Statisticians Discuss the DMC Process
Panelists:	Paul Gallo, Novartis Walt Offen, AbbVie Markus Abt, Roche/Genentech Gordon Sun, BioMarin Gary Aras, Amgen
8:55 AM	Floor Discussion

677 * !	Thu, 8/4/2016, 10:30 AM - 12:20 PM	CC-W175a
The Good, the Bad, and the Messy: Innovations in Analysis of Electronic Medical Records — Invited Papers
Section on Statistical Learning and Data Science , Committee on Applied Statisticians
Organizer(s): Ruth Etzioni, Fred Hutchinson Cancer Research Center, Suchi Saria, The Johns Hopkins University
Chair(s): Frank Yoon, Mathematica Policy Research
10:35 AM	Missing Data as a Causal and Probabilistic Problem — Ilya Shpitser, Johns Hopkins Computer Science
11:00 AM	Individualizing Prognosis of Disease Trajectories Using Longitudinal Electronic Medical Record Data: Application to Scleroderma — Suchi Saria, The Johns Hopkins University ; Peter Schulam, The Johns Hopkins University
11:25 AM	New Machine-Learning Approaches to Causal Inference — Cynthia Rudin, Duke University
11:50 AM	Discussant: Ruth Etzioni, Fred Hutchinson Cancer Research Center
12:10 PM	Floor Discussion

JSM 2016 Online Program

Activity Details

ASA Meetings Department

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