Conference Program Home
My Program
All Times EDT
Legend:
CC = Walter E. Washington Convention Center M = Marriott Marquis Washington, DC
* = applied session ! = JSM meeting theme
Activity Details
18 * !
Sun, 8/7/2022,
2:00 PM -
3:50 PM
CC-143C
New Models, Diagnostics, and Considerations in Evaluating Intervention and Policy Effects — Topic Contributed Papers
Health Policy Statistics Section , Biometrics Section, WNAR
Organizer(s): Maricela Cruz, Kaiser Permanente Washington Health Research Institute
Chair(s): Mary Ryan, Yale Center for Analytical Sciences
2:05 PM
No Free Lunch: A Noninferiority Approach to Model Assumption Tests
Laura Hatfield, Harvard Medical School ; Alyssa Bilinski, Brown University
2:25 PM
Assessing the Impact of Using County Versus State Level Outcomes Data in the Evaluation of State-Level Opioid Policies
Beth Ann Ann Griffin, RAND Corporation ; Elizabeth Stuart, Johns Hopkins University; Megan Schuler, RAND; Nabarun Dasgupta, Gillings School of Global Public Health; Rosalie Liccardo Pacula, University of Southern California, Los Angeles, CA 90089; David Powell, RAND
2:45 PM
Marginalized Three-Part Beta Interrupted Time Series Regression Models for Proportional Data Analysis
Shangyuan Ye, Oregon Health and Science University
3:05 PM
A Mixed-Effects Interrupted Time Series Model for Assessing Complex Health Care Interventions Across Multiple Units
Maricela Cruz, Kaiser Permanente Washington Health Research Institute ; Andrew Holbrook, UCLA Biostatistics; Daniel L Gillen, University of California Irvine
3:25 PM
A Parametric Bootstrapping Approach for Time Series Analysis in Large Claims Databases
Fang Zhang, Harvard Pilgrim Health Care ; Meghan Mayhew, kaiser permanente center for health research; Frank Wharam, Duke University; Ladia Albertson-junkans, Kaiser Permanente Washington Health Research Institute; Arvind Ramaprasan, Kaiser Permanente Washington Health Research Institute
3:45 PM
Floor Discussion
45 * !
Sun, 8/7/2022,
4:00 PM -
5:50 PM
CC-150B
Recent Development in Mobile/Wearable Device Data Analysis — Invited Papers
Health Policy Statistics Section , ENAR, IMS
Organizer(s): Jingjing Zou, University of California at San Diego (UCSD)
Chair(s): Loki Natarajan, University of California at San Diego (UCSD)
4:05 PM
A Novel Functional Data Analysis Approach to Modeling Longitudinal Changes in Physical Activity Patterns
Jingjing Zou, University of California at San Diego (UCSD) ; Tuo Lin, University of California San Diego; Chongzhi Di, Fred Hutchinson Cancer Research Center; John Bellettiere, UCSD; Marta Jankowska, Beckman Research Institute, City of Hope; Sheri J. Hartman, University of California, San Diego; Dorothy D. Sears, Arizona State University and University of California, San Diego; Andrea LaCroix, UCSD; Cheryl Rock, University of California, San Diego; Loki Natarajan, University of California at San Diego (UCSD)
4:30 PM
Distributional Data Analysis via Quantile Functions and Its Application to Modeling Digital Biomarkers
Vadim Zipunnikov, Johns Hopkins University, Bloomberg School of Public Health ; Rahul Ghosal, Johns Hopkins University, Bloomberg School of Public Health
4:55 PM
Improving Efficiency of Causal Excursion Effect Estimation via Machine Learning
Tianchen Qian, University of California, Irvine ; Zhaoxi Cheng, Harvard University
5:20 PM
Measuring Variability in Rest-Activity Rhythms with Application to Characterizing Symptoms of Depression
Robert T Krafty, Emory University ; Haoyi Fu, University of Pittsburgh; Jessica Graves, University of Pittsburgh; Scott Bruce, Texas A&M University; Martica Hall, University of Pittsburgh; Stephen Smagula, University of Pittsburgh
5:45 PM
Floor Discussion
61 * !
Sun, 8/7/2022,
4:00 PM -
5:50 PM
CC-154A
Population Inference with Electronic Health Records (EHRs) Data: Addressing Selection and Representativeness Bias — Topic Contributed Panel
Survey Research Methods Section , Health Policy Statistics Section, Section on Statistics in Epidemiology
Organizer(s): Jasmin Divers, NYU Long Island School of Medicine
Chair(s): Rebecca Anthopolos, NYU Grossman School of Medicine
4:05 PM
Population Inference with Electronic Health Records (EHRs) Data: Addressing Selection and Representativeness Bias
Panelists:
Yu B Chen, CDC
Sarah Conderino, NYU Grossman School of Medicine
Imaani Easthausen, Aetion
Emily Pfaff, University of North Carolina at Chapel Hill
Judy Zhong, New York University Grossman School of Medicine
Bo Cai, University of South Carolina, Arnold School of Public Health
5:40 PM
Floor Discussion
85 * !
Mon, 8/8/2022,
8:30 AM -
10:20 AM
CC-150A
20 Years of Principal Stratification: Where to Now? — Invited Papers
Health Policy Statistics Section , Mental Health Statistics Section, Biometrics Section, Caucus for Women in Statistics
Organizer(s): Booil Jo, Stanford University
Chair(s): Peng Ding, University of California Berkeley
8:35 AM
Jointly Utilizing Parametric and Nonparametric Identification of Principal Causal Effects
Booil Jo, Stanford University
8:55 AM
The Role of Principal Stratification in Pharmaceutical Experimentation: The Estimand Strategy
Fabrizia Mealli, University of Florence
9:15 AM
Experimental Evaluation of Algorithm-Assisted Human Decision-Making: Application to Pretrial Public Safety Assessment
Zhichao Jiang, University of Massachusetts Amherst
9:35 AM
Bridging Theory and Practice in Principal Stratification
Presentation
Fan Li, Duke University ; Bo Liu, Duke University
9:55 AM
Discussant: Constantine Frangakis, Johns Hopkins University
10:15 AM
Floor Discussion
125 * !
Mon, 8/8/2022,
10:30 AM -
12:20 PM
CC-150B
Practical Recommendations for Prediction Modeling That Advance Innovation — Invited Papers
Section on Statistical Learning and Data Science , Biometrics Section, Health Policy Statistics Section
Organizer(s): Jaime Lynn Speiser, Wake Forest School of Medicine
Chair(s): Heather Shappell, Wake Forest School of Medicine
10:35 AM
Variable Selection with Random Forest: Choosing the Best Method for Different Types of Data
Jaime Lynn Speiser, Wake Forest School of Medicine
10:55 AM
Current Methods for Evaluating Prediction Model Performance
Michael W. Kattan, Cleveland Clinic
11:15 AM
Cross Validation for Small and Imbalanced Data
Nathaniel O'Connell, Wake Forest School of Medicine
11:35 AM
Disseminating Prediction Methods: Avoiding Computational Bottlenecks and Developing User-Friendly APIs
Byron Casey Jaeger, Wake Forest School of Medicine
11:55 AM
Discussant: Joseph Rigdon, Wake Forest School of Medicine
12:15 PM
Floor Discussion
131 *
Mon, 8/8/2022,
10:30 AM -
12:20 PM
CC-159AB
Translating Health Outcome Data into Real-World Understanding and Policies — Topic Contributed Papers
Health Policy Statistics Section , Business and Economic Statistics Section, Biopharmaceutical Section
Organizer(s): Heejung Bang, Division of Biostatistics, University of California
Chair(s): Heejung Bang, Division of Biostatistics, University of California
10:35 AM
An Influence Function Based Instrumental Variable Estimator of Censored Medical Costs
Nicholas Illenberger, New York University ; Nandita Mitra, University of Pennsylvania; Luke Keele, University of Pennsylvania
10:55 AM
Optimizing Tailored Intervention in Cost-Effectiveness Analysis
Shuai Chen, University of California, Davis
11:15 AM
The Diffusion of Health Care Fraud: A Network Analysis
James O'Malley, Geisel School of Medicine at Dartmouth ; Thomas Bubolz, Geisel School of Medicine at Dartmouth; Jonathan S Skinner, Dartmouth College
11:35 AM
Measuring Health Care Quality: Opportunities and Challenges for Addressing Social Determinants of Health
Presentation
Sophia Chan, Centers for Medicare and Medicaid Services (CMS)
11:55 AM
Floor Discussion
138 * !
Mon, 8/8/2022,
10:30 AM -
12:20 PM
CC-202B
Dose Optimization in Drug Development: Where We Are, and Where We Want to Be — Topic Contributed Papers
Biopharmaceutical Section , Biometrics Section, Health Policy Statistics Section
Organizer(s): Bo Huang, Pfizer Inc.
Chair(s): Bo Huang, Pfizer Inc.
10:35 AM
A Bayesian Predictive Platform Design for Proof of Concept and Dose-Finding Using Early and Late Endpoints
Ruitao Lin, MD Anderson; Li Wang, Abbvie ; Peter Thall, The University of Texas MD Anderson Cancer Center; Ying Yuan , the University of Texas MD Anderson Cancer Center
10:55 AM
Statistical Methods for Dose Optimization in Oncology; One Size Does Not Fit All
Roberto Bugarini, Pfizer Inc. ; Wei Zhong, Pfizer Inc.; Christophe Le Corre, Pfizer Inc.; Cynthia Basu, Pfizer Inc.; Ray Li, Pfizer Inc.
11:15 AM
Dose-Finding in Retinal Gene Therapy Trials – Optical Illusion or Not?
Jialin Xu, Janssen ; George Capuano, Janssen
11:35 AM
Data-Informed Oncology Dosing Decisions: Trade-Off Between Efficacy/Safety/Convenience Including a Case Study with a Bi-Specific Immunotherapy
Erik Rasmussen, Amgen
11:55 AM
Bayesian Approaches to Identify Multiple Recommended Phase 2 Doses
Erik Bloomquist, Ph.D. ; Jianjin Xu, FDA/CDER
12:15 PM
Floor Discussion
174 * !
Mon, 8/8/2022,
2:00 PM -
3:50 PM
CC-202A
Patient Centricity at the Heart of Innovative Trial Design — Invited Papers
Biopharmaceutical Section , International Indian Statistical Association, Health Policy Statistics Section
Organizer(s): Satrajit Roychoudhury, Pfizer Inc
Chair(s): Satrajit Roychoudhury, Pfizer Inc
2:05 PM
The Predictive Individual Effect for Survival Data
Kannan Natarajan, Pfizer
2:30 PM
The Impact of Complex Innovative Trial Designs: Past, Present, and Future
Dionne Price, Food and Drug Administration
2:55 PM
Deliver Transformative Medicines to Patients by Leveraging Complex Innovative Designs
Amy Xia, Amgen
3:20 PM
Innovations to Ascertain Predictive from Prognostic Targets
Brian P Hobbs, The University of Texas
3:45 PM
Floor Discussion
200 * !
Mon, 8/8/2022,
2:00 PM -
3:50 PM
CC-144A
Statistical Methods in Policy Evaluation: From COVID-19 to Medical Cannabis–Related Policy — Contributed Papers
Health Policy Statistics Section
Chair(s): Mousumi Banerjee, University of Michigan
2:05 PM
New Approach to Quantify COVID-19 Policy Effectiveness and Related Factors
Yile He, University of California, Davis
2:20 PM
Leveraging Heterogeneity in Infectivity to Improve Efficiency in Contact Tracing
Presentation
Aparajithan Venkateswaran, University of Washington ; Tyler McCormick, University of Washington; Jishnu Das, Georgetown University
2:35 PM
Estimating Causal Effects of the Philadelphia Beverage Tax Policy in the Presence of Spillover
Gary Hettinger, University of Pennsylvania ; Youjin Lee, Brown University; Nandita Mitra, University of Pennsylvania
2:50 PM
Rolling with the Punches: Evaluating Policy Interventions with Rolling Enrollment
Jonathan Gellar, Mathematica ; Lauren Vollmer, Mathematica Policy Research; Keith Kranker, Mathematica
3:05 PM
Analyzing the Impact of Different Countries’ Approaches to the COVID-19 Pandemic on Their Cumulative Infection Curves by Using Nonparametric Density Regression and Clustering Methods
Edithe Lam, Stanford OHS ; Dashmi Singh, Stanford OHS; Nicholas Lu, Stanford OHS; Mason Chen, Stanford OHS; Damian Musk, Stanford OHS
3:20 PM
Handling Correlation in Stacked Difference-in-Differences Estimates with Application to Medical Cannabis Policy
Nicholas Joseph Seewald, Johns Hopkins Bloomberg School of Public Health ; Kayla Tormohlen, Johns Hopkins Bloomberg School of Public Health; Beth McGinty, Johns Hopkins Bloomberg School of Public Health; Elizabeth Stuart, Johns Hopkins University
3:35 PM
Floor Discussion
232 * !
Tue, 8/9/2022,
8:30 AM -
10:20 AM
CC-202B
Health Policy Statistics Section Student Paper Award — Topic Contributed Papers
Health Policy Statistics Section , Health Policy Statistics Section, Health Policy Statistics Section
Organizer(s): Summer S Han, Stanford University
Chair(s): Theresa Kim, NIH
8:35 AM
Doubly Robust Semiparametric U-Statistic with Applications in Biomedical Studies
Anqi Yin, Georgetown University ; Ao Yuan, Georgetown University; Ming Tan, Georgetown University
8:55 AM
Bayesian Data Synthesis and the Utility-Risk Trade-Off for Mixed Epidemiological Data
Joseph Feldman, Rice University ; Daniel Kowal, Rice University
9:15 AM
Defining R-Squared Measures for Mixed-Effects Location Scale Models
Xingruo Zhang, The University of Chicago ; Donald Hedeker, The University of Chicago
9:35 AM
Bayesian Unanchored Additive Models for Component Network Meta-Analysis
Augustine Wigle, University of Waterloo ; Audrey Beliveau, University of Waterloo
9:55 AM
Evidence Synthesis with Reconstructed Survival Data
Chenqi Fu, Pennsylvania State University ; Shouhao Zhou, Pennsylvania State University
10:15 AM
Floor Discussion
241
Tue, 8/9/2022,
8:30 AM -
10:20 AM
CC-140B
SPEED: Statistics in Social Sciences and Survey Research Part 1 — Contributed Speed
Business and Economic Statistics Section , Survey Research Methods Section, Quality and Productivity Section, ENAR, Government Statistics Section, Health Policy Statistics Section, Lifetime Data Science Section
Chair(s): Jiaxin Hu, University of Wisconsin-Madison
8:35 AM
Dynamic Models for Corporate Competitiveness of Global Health Care Industry with Mixed Effects
Mingzhao Hu, University of California, Santa Barbara ; Lingdi Zhao, Ocean University of China; Danlei Feng, Ocean University of China
8:40 AM
A Mixed Model Approach for Dynamic Trade Networks
Burcu Eke Rubini, University of New Hampshire ; Loris Rubini, University of New Hampshire
8:45 AM
Using R Packages for Weekly Seasonal Adjustment
Brian Carl Monsell, Bureau of Labor Statistics
8:50 AM
Privacy Secure Aggregation of the Individual Models into a Federated Model with Bayesian MCMC Bootstrapping
Eugene Yankovsky, EY ; Ana Yankovsky, Inuitive Surgical
8:55 AM
The Inequality Process (IP) as Statistical Mechanics: How the IP’s Internal Model Enables Symmetries, Frame Independence, and the Search for the IP's Lagrangian Analogue
John Angle, The Inequality Process Institute
9:00 AM
Adapting COVID-19 Early Release Data to Determine Impact of Opioid Use in Hospital Emergency Departments
Salah Shaikh, National Center for Health Statistics (NCHS) - CDC
9:05 AM
Comparing Methods for Weighting to Extend Inferences from a Collection of Trials
Nicole Schnitzler, The Ohio State University ; Eloise E Kaizar, The Ohio State University
9:10 AM
Examining the Effects of Contamination Due to School Mobility on Efficacy of Stepped Wedge Designs
Meredith McCormack-Mager, The Ohio State University ; Abigail Shoben, The Ohio State University
9:15 AM
Results of a Push-to-Web Protocol in a Survey of Commercial Buildings
Katie Lewis, Energy Information Administration ; Sarah Grady, Energy Information Administration; Lawrence Chrishelle, Energy Information Administration
9:20 AM
Using Effect Sizes to Quantify the Difference Between Survival Functions
Huan Wang, Division of Biometrics IX, OB/OTS/CDER, FDA
9:30 AM
Model-Robust Experimentation Strategy for Estimation of Expensive Black-Box Functions with Mixed Quantitative and Qualitative Factors
Gautham Sunder, Carlson School of Management ; Christopher Nachtsheim, Carlson School of Management
9:35 AM
A Statistical Model Predicting Final Yield During Data Collection
Rui Jiao, WESTAT; Daniel Guzman, META; Sabrina Zhang, Westat ; Andrea Piesse, WESTAT
9:40 AM
WITHDRAWN An Empirical Evaluation of Probabilistic File Linking Techniques
Gauri Kamat, Brown University; Roee Gutman, Brown University
9:45 AM
Extending MRP to Incorporate Variables with Unknown Distributions
Brittany Marie Alexander, Ipsos Public Affairs
9:50 AM
Predicting Call Sequence Length in the Telephone Mode Using Prediction Algorithms
Xinyu Zhang, University of Michigan ; James Wagner, University of Michigan
9:55 AM
A Modified Proportional Allocation Sampling Method for the Study of Respirator Use and Practices in U.S. Private Industries
Danny Friel, U.S. Bureau of Labor Statistics ; Michelle Myers, U.S. Bureau of Labor Statistics; Dee Zamora, U.S. Bureau of Labor Statistics; Xingyou Zhang, U.S. Bureau of Labor Statistics; Katherine N. Yoon, National Institute for Occupational Safety and Health; Megan Casey, National Institute for Occupational Safety and Health; Emily J. Haas, National Institute for Occupational Safety and Health
10:00 AM
Synthetic Data Generation for Complex Surveys
Shirley Mathur, Duke University ; Jerome P. Reiter, Duke University
10:05 AM
WITHDRAWN Demographic Edit and Imputation for Multilevel Data from the FBI’s National Incident Based Reporting System
Philip Lee, RTI; Amang Sukasih, RTI; Dan Liao, RTI; Marcus Berzofsky, RTI International; Alexia Cooper, RTI
10:10 AM
Floor Discussion
294
Tue, 8/9/2022,
10:30 AM -
11:15 AM
CC-Hall D
SPEED: Statistics in Social Sciences and Survey Research Part 2 — Contributed Poster Presentations
Business and Economic Statistics Section , Survey Research Methods Section, Quality and Productivity Section, ENAR, Government Statistics Section, Health Policy Statistics Section, Lifetime Data Science Section
Chair(s): Jiaxin Hu, University of Wisconsin-Madison
01:
Dynamic Models for Corporate Competitiveness of Global Health Care Industry with Mixed Effects
Mingzhao Hu, University of California, Santa Barbara ; Lingdi Zhao, Ocean University of China; Danlei Feng, Ocean University of China
02:
A Mixed Model Approach for Dynamic Trade Networks
Burcu Eke Rubini, University of New Hampshire ; Loris Rubini, University of New Hampshire
03:
Using R Packages for Weekly Seasonal Adjustment
Brian Carl Monsell, Bureau of Labor Statistics
04:
Privacy Secure Aggregation of the Individual Models into a Federated Model with Bayesian MCMC Bootstrapping
Eugene Yankovsky, EY ; Ana Yankovsky, Inuitive Surgical
05:
The Inequality Process (IP) as Statistical Mechanics: How the IP’s Internal Model Enables Symmetries, Frame Independence, and the Search for the IP's Lagrangian Analogue
John Angle, The Inequality Process Institute
06:
Adapting COVID-19 Early Release Data to Determine Impact of Opioid Use in Hospital Emergency Departments
Salah Shaikh, National Center for Health Statistics (NCHS) - CDC
07:
Comparing Methods for Weighting to Extend Inferences from a Collection of Trials
Nicole Schnitzler, The Ohio State University ; Eloise E Kaizar, The Ohio State University
08:
Examining the Effects of Contamination Due to School Mobility on Efficacy of Stepped Wedge Designs
Meredith McCormack-Mager, The Ohio State University ; Abigail Shoben, The Ohio State University
09:
Results of a Push-to-Web Protocol in a Survey of Commercial Buildings
Katie Lewis, Energy Information Administration ; Sarah Grady, Energy Information Administration; Lawrence Chrishelle, Energy Information Administration
10:
Using Effect Sizes to Quantify the Difference Between Survival Functions
Huan Wang, Division of Biometrics IX, OB/OTS/CDER, FDA
11:
Model-Robust Experimentation Strategy for Estimation of Expensive Black-Box Functions with Mixed Quantitative and Qualitative Factors
Gautham Sunder, Carlson School of Management ; Christopher Nachtsheim, Carlson School of Management
12:
Specifying Prior Distributions in Reliability Applications
Colin Lewis-Beck, Eli Lilly; William Meeker, Iowa State; Qinglong Tian, University of Wisconsin ; Jarad Niemi, Iowa State
13:
A Statistical Model Predicting Final Yield During Data Collection
Rui Jiao, WESTAT; Daniel Guzman, META; Sabrina Zhang, Westat ; Andrea Piesse, WESTAT
14:
WITHDRAWN An Empirical Evaluation of Probabilistic File Linking Techniques
Gauri Kamat, Brown University; Roee Gutman, Brown University
15:
Extending MRP to Incorporate Variables with Unknown Distributions
Brittany Marie Alexander, Ipsos Public Affairs
16:
Predicting Call Sequence Length in the Telephone Mode Using Prediction Algorithms
Xinyu Zhang, University of Michigan ; James Wagner, University of Michigan
17:
A Modified Proportional Allocation Sampling Method for the Study of Respirator Use and Practices in U.S. Private Industries
Danny Friel, U.S. Bureau of Labor Statistics ; Michelle Myers, U.S. Bureau of Labor Statistics; Dee Zamora, U.S. Bureau of Labor Statistics; Xingyou Zhang, U.S. Bureau of Labor Statistics; Katherine N. Yoon, National Institute for Occupational Safety and Health; Megan Casey, National Institute for Occupational Safety and Health; Emily J. Haas, National Institute for Occupational Safety and Health
18:
Synthetic Data Generation for Complex Surveys
Shirley Mathur, Duke University ; Jerome P. Reiter, Duke University
19:
WITHDRAWN Demographic Edit and Imputation for Multilevel Data from the FBI’s National Incident Based Reporting System
Philip Lee, RTI; Amang Sukasih, RTI; Dan Liao, RTI; Marcus Berzofsky, RTI International; Alexia Cooper, RTI
314 * !
Tue, 8/9/2022,
2:00 PM -
3:50 PM
CC-149AB
Pioneering Statistical Methods to Alleviate Health Disparity and Achieve Health Equity — Invited Papers
Health Policy Statistics Section , Academy for Health Services Research and Health Policy, Society for Medical Decision Making, Justice Equity Diversity and Inclusion Outreach Group
Organizer(s): Chen-Pin Wang, University of Texas Health San Antonio
Chair(s): Barry Graubard , National Cancer Institute (NCI)
2:05 PM
Health Disparity for Complex Survey Data
Barry Graubard , National Cancer Institute (NCI); Joseph L. Gastwirth, The George Washington University; Mi-Ok Kim, UCSF; Hyokyoung (Grace) Hong, NCI/NIH
2:25 PM
The Geography of Structural Racism: From Operationalization to Measuring Spatial (and Spatio-Temporal) Heterogeneity: How Important Is Residential Segregation?
Loni Philip Tabb, Dornsife School of Public Health, Drexel University ; Yang Xu, Drexel University
2:45 PM
An Integrated Approach to Assess Heterogeneity in Health Disparity
Chen-Pin Wang, University of Texas Health San Antonio ; Booil Jo, Stanford University
3:05 PM
Discussant: John W Jackson, Johns Hopkins University
3:25 PM
Discussant: Elizabeth Stuart, Johns Hopkins University
3:45 PM
Floor Discussion
361 * !
Wed, 8/10/2022,
8:30 AM -
10:20 AM
CC-202B
Using Statistical Foundations to Demonstrate Effectiveness of ML/AI Algorithms for Clinical Utility — Invited Papers
Biopharmaceutical Section , Section on Statistical Learning and Data Science, Health Policy Statistics Section
Organizer(s): Charmaine Demanuele, Pfizer; Stephen J Ruberg, Analytix Thinking, LLC
Chair(s): Sandeep M Menon, Pfizer, Inc.
8:35 AM
Deep Learning for Image Analysis - Initial Development of Digital Diagnostic/Prognostic Algorithms: Analogies and Lessons Learned from Drug Development
Chong Duan, Pfizer
9:00 AM
Optimizing Digital Diagnostic/Prognostics Algorithms: A New Framework and Approach Beyond Area Under the Receiver Operating Characteristic Curve
Presentation
Stephen J Ruberg, Analytix Thinking, LLC
9:25 AM
Clinical Trial Designs to Estimate the Effect of a Digital Diagnostic/Prognostic Algorithm in Clinical Practice: Application of Cluster-Randomized Designs
Liz Turner, Duke University
9:50 AM
Discussant: John Quackenbush, Harvard T.H. Chan School of Public Health
10:15 AM
Floor Discussion
375 * !
Wed, 8/10/2022,
8:30 AM -
10:20 AM
CC-203AB
Causal Estimand in Clinical Trials — Topic Contributed Papers
Biometrics Section , Biopharmaceutical Section, Health Policy Statistics Section
Organizer(s): Lei Nie, U. S. FDA
Chair(s): Frank Bretz, Novartis
8:35 AM
Covariate Adjustment and Missing Data in Clinical Trials
Daniel Rubin, U.S. Food and Drug Administration
8:55 AM
Estimating the Average Treatment Effect in Randomized Clinical Trials with All-or-None Compliance
Zhiwei Zhang, National Cancer Institute/National Institutes of Health ; Zonghui Hu, National Institutes of Health; Dean Follmann, National Institute of Allergy and Infectious Diseases; Lei Nie, U. S. FDA
9:15 AM
Estimands and Their Estimators for Clinical Trials Impacted by the COVID-19 Pandemic
Kelly Van Lancker, Johns Hopkins University, Bloomberg School of Public Health, US and Ghent University, Belgium ; Sergey Tarima, Division of Biostatistics, Medical College of Wisconsin; Jonathan Bartlett, University of Bath; Madeline Bauer, Division of Infectious Diseases, Keck School of Medicine, University of Southern Californi; Bharani Bharani-Dharan, Novartis Pharmaceuticals; Frank Bretz, Novartis; Nancy Flournoy, University of Missouri; Hege Michiels, Ghent University; Camila Olarte Parra, University of Bath; James Landis Rosenberger, Penn State and NISS; Suzie Cro, Imperial Clinical Trials Unit, Imperial College London
9:35 AM
Discussant: Wanjie Sun, The US FDA
9:55 AM
Discussant: Tianmeng Lyu, Novartis
10:15 AM
Floor Discussion
411 *
Wed, 8/10/2022,
10:30 AM -
12:20 PM
CC-158AB
Addressing Key Issues to Promote the Uptake of Using RWE/D for Regulatory Decisions — Topic Contributed Papers
Biopharmaceutical Section , Stats. Partnerships Among Academe Indust. & Govt. Committee, Health Policy Statistics Section
Organizer(s): Yixin Fang, AbbVie
Chair(s): Hana Lee, FDA
10:35 AM
Estimands in Real-World Studies
Jie Chen, Overland Pharmaceuticals
10:55 AM
Statistical Consideration for Fit-For-Use Real-World Data to Support Regulatory Decision Making in Drug Development
Weili He, AbbVie
11:15 AM
Sensitivity Analyses for Unmeasured Confounding: A Path Forward?
Douglas Faries, Eli Lilly & Company
11:35 AM
Examples of Applying Causal Inference Framework in Real-World Settings
Presentation
Yixin Fang, AbbVie
11:55 AM
Discussant: Mark Levenson, FDA
12:15 PM
Floor Discussion
423 * !
Wed, 8/10/2022,
10:30 AM -
12:20 PM
CC-140A
Topics in Health Services Research: Meta-Analysis, Health Care Disparities, and Observational Data — Contributed Papers
Health Policy Statistics Section
Chair(s): Steven Cohen, RTI
10:35 AM
An Integrated Abundance Model for Estimating County-Level Prevalence of Opioid Misuse in Ohio
Staci Hepler, Wake Forest University ; David Kline, Wake Forest University; Lance Waller, Rollins School of Public Health, Emory University
10:50 AM
Variance Decomposition on Cluster Level for Binary Outcomes in Application to Cancer Care Disparity Studies
Hajime Uno, Dana-Farber Cancer Insitute ; Angela Tramontano, Dana-Farber Cancer Institute; Rinaa Punglia, Dana-Farber Cancer Institute; Michael J. Hassett, Dana-Farber Cancer Institute
11:05 AM
An Index of Sensitivity to Nonexchangeability
Presentation
Md Rashedul Hoque, Simon Fraser University ; Yi Qian, University of British Columbia; Lawrence McCandless, Simon Fraser University; J Antonio Aviña-Zubieta, University of British Columbia; Mary A De Vera, Simon Fraser University; Hui Xie, Simon Fraser University
11:20 AM
RIMeta: A Shiny App for Estimating Reference Interval from Meta-Analysis
Ziren Jiang, University of Minnesota ; Wenhao Cao, Division of Biostatistics, University of Minnesota; Haitao Chu, Pfizer Inc.; Lianne Siegel, University of Minnesota
11:35 AM
Floor Discussion
463 * !
Wed, 8/10/2022,
2:00 PM -
3:50 PM
CC-206
Recent Innovations in Method Developments for Risk-Based Screening and Health Policy Modeling for Cancer — Invited Papers
Section on Risk Analysis , Health Policy Statistics Section, Korean International Statistical Society
Organizer(s): Eunji Choi, Stanford University School of Medicine
Chair(s): Eunji Choi, Stanford University School of Medicine
2:05 PM
Incorporating Polygenic Risk Scores into Health Screening
John Witte, Stanford University
2:30 PM
From DNA to Decision: Will Germline Genomic Risk Fulfill Its Promise?
Ruth Etzioni, Fred Hutch Cancer Research Center
2:55 PM
Evidence-Based Screening Criteria for Second Primary Lung Cancer Using a Risk Prediction Model for Lung Cancer Survivors
Summer S Han, Stanford University ; Eunji Choi, Stanford University School of Medicine; Sophia Luo, Stanford University; Heather Wakelee, Stanford University
3:20 PM
Risk-Based Selection of Individuals for Oral Cancer Screening
Li C Cheung, National Cancer Institute, Division of Cancer Epidemiology and Genetics
3:45 PM
Floor Discussion
467 * !
Wed, 8/10/2022,
2:00 PM -
3:50 PM
CC-144B
Alternative Data Sources Utilization in Clinical Development — Topic Contributed Papers
Health Policy Statistics Section , Social Statistics Section, Biopharmaceutical Section
Organizer(s): Freda Cooner, Amgen
Chair(s): Judy Li, Bristol Myers Squibb
2:05 PM
Achieving Regulatory Approval Using Real-World Evidence: Challenges and Considerations
Tae Hyun (Ryan) Jung, US FDA
2:25 PM
Bridging the Gap Between Clinical Trial and Real World Data: A Framework for Working with Real-World Data in Clinical Development
Laura L Fernandes, COTA Healthcare
2:45 PM
Industry Applications of RWD to Advance Drug Development and Inform Regulatory Decision-Making
May Mo, Amgen
3:05 PM
Illustration of Propensity Score Weighted External Control with Single Arm Phase 2 Trial and Hybrid Randomized and External Control in Phase 3 Design in Recurrent Glioblastoma
Ruthie Davi, Acorn AI by Medidata
3:25 PM
Discussant: Yueqin Zhao, Food and Drug Administration
3:45 PM
Floor Discussion
476 !
Wed, 8/10/2022,
2:00 PM -
3:50 PM
CC-201
Beyond Propensity Scores: Novel Techniques in Utilizing Real-World Data in Clinical Trials — Topic Contributed Papers
ENAR , Health Policy Statistics Section, Biometrics Section
Organizer(s): Yuanyuan Bian, Eli Lilly and Company
Chair(s): Ran Liao, Eli Lilly and Company
2:05 PM
Bayesian Divide-and-Conquer Propensity Score-Based Approaches for Leveraging Real-World Data in Single-Arm Clinical Trials
Eric Baron, University of Connecticut; Jian Zhu, Servier Pharmaceuticals; Sammi Tang, Servier Pharmaceuticals; Ming-Hui Chen, University of Connecticut
2:25 PM
Integrating Real-World Data and Clinical Trial Results Using Survival Data Reconstruction and Marginal Moment-Balancing Weights
Kylie Getz, Rutgers School of Public Health ; Ronac Mamtani, University of Pennsylvania; Rebecca Hubbard, University of Pennsylvania
2:45 PM
Power Priors with Entropy Balancing Weights in Data Augmentation of Partially Controlled Randomized Trials
Guanglei Yu, Eli Lilly and Company; Yuanyuan Bian, Eli Lilly and Company ; Margaret Gamalo , Pfizer Inc.
3:05 PM
Challenges and Potential Strategies Utilizing External Data for Efficacy Evaluation in Small-Sized Clinical Trials
Feiran Jiao, FDA ; Yeh-Fong Chen, Food and Drug Administration
3:25 PM
Matching Within a Hybrid RCT/RWD: Framework on Associated Causal Estimands
Guanglei Yu, Eli Lilly and Company ; Margaret Gamalo , Pfizer Inc.; Junjing Lin, Takeda Pharmaceuticals
3:45 PM
Floor Discussion
513 * !
Thu, 8/11/2022,
8:30 AM -
10:20 AM
CC-143C
Bayesian Learning for the Health Care and Disparities in the 21st Century — Topic Contributed Papers
International Society for Bayesian Analysis (ISBA) , Biometrics Section, Health Policy Statistics Section
Organizer(s): Anjishnu Banerjee, Medical College of Wisconsin
Chair(s): Anjishnu Banerjee, Medical College of Wisconsin
8:35 AM
Bayesian Nonlinear Models for Data Integration and Distributed Statistical Inference
sounak chakraborty, university of missouri ; Tanujit Dey, Harvard University; Anjishnu Banerjee, Medical College of Wisconsin
8:55 AM
Robust Inference on Uncomfirming Silos
Yilun Huang, University of Missouri-Columbia ; sounak chakraborty, university of missouri; Tanujit Dey, Harvard University; Anjishnu Banerjee, Medical College of Wisconsin
9:15 AM
Transformation into Next-Generation Risk Management Through Bayesian Lag Joint Model
Yan Gao, Medical College of Wisconsin ; Sanjib Basu, Biostatistics, University of Illinois Chicago
9:35 AM
Bayesian Learning for Disparities and Race Related Measures from Integrated Data Sources, Using Rare Event and Hierarchical Models
Tanujit Dey, Harvard University ; Anjishnu Banerjee, Medical College of Wisconsin; sounak chakraborty, university of missouri
9:55 AM
Discussant: Srijan Sengupta, NCSU
10:15 AM
Floor Discussion
528 * !
Thu, 8/11/2022,
10:30 AM -
12:20 PM
CC-154B
Advances in Social Network Analysis for Public Health Solutions — Invited Papers
Section on Statistics in Epidemiology , Health Policy Statistics Section
Organizer(s): Youjin Lee, Brown University
Chair(s): Youjin Lee, Brown University
10:35 AM
New Approaches to Model Multi-Level Social Networks for Evaluating the Impact of Demographics on Health Disparities of Epidemic Trajectories in the NYC Population
Natallia V. Katenka, University of Rhode Island ; Ashley Buchanan, University of Rhode Island
11:00 AM
Causal Identification for Infectious Disease Intervention in Network
Xiaoxuan Cai, Columbia University ; Forrest W. Crawford, Yale University; Eben Kenah, The Ohio State University
11:25 AM
Causal Estimation of Intervention Spillover Effects in Egocentric Network-Randomized Trials in the Presence of Network Misclassification
Ariel Chao, Yale School of Public Health ; Laura Forastiere, Yale School of Public Health; Ashley Buchanan, University of Rhode Island; Sten Vermund, Yale School of Public Health; Donna Spiegelman, Yale School of Public Health
11:50 AM
Discussant: Gabrielle Lemire, Montana State University
12:15 PM
Floor Discussion
534 * !
Thu, 8/11/2022,
10:30 AM -
12:20 PM
CC-158AB
Tradeoff Between Risks and Benefits When Transporting Model Under Distribution Shift — Invited Papers
ENAR , Section on Risk Analysis, Health Policy Statistics Section
Organizer(s): Jiwei Zhao, University of Wisconsin-Madison
Chair(s): Jiwei Zhao, University of Wisconsin-Madison
10:35 AM
Learning by Combining Data from Multiple Sources: Causal Assumptions, Study Design, Sampling Properties, and Estimation
Issa J. Dahabreh, Harvard University
11:00 AM
Some Results on Label Shift and Label Noise
Zachary Chase Lipton, Carnegie Mellon University
11:25 AM
Generalizable Prediction of Ultrafine Particle Concentration Using Combined Multi-Site Measurements
Prasad Patil, Boston University School of Public Health ; Sean Mueller, Boston University School of Public Health; Neelakshi Hudda, Tufts University; John Durant, Tufts University; Jon Levy, Boston University School of Public Health; Kevin Lane, Boston University School of Public Health
11:50 AM
Leveraging Observational Outcomes to Improve the Generalizability of Experimental Results
Melody Huang, University of California, Berkeley ; Naoki Egami, Columbia University; Erin Hartman, University of California, Berkeley; Luke Miratrix, Harvard University
12:15 PM
Floor Discussion
535 !
Thu, 8/11/2022,
10:30 AM -
12:20 PM
CC-144B
Learning Individualized Treatment Rules in Complex Settings — Invited Papers
Health Policy Statistics Section , Social Statistics Section, Government Statistics Section
Organizer(s): Eli Ben-Michael, Harvard University
Chair(s): Kosuke Imai, Harvard University
10:35 AM
Safe Policy Learning Through Extrapolation: Application to Pre-Trial Risk Assessment
Eli Ben-Michael, Harvard University ; Jim Greiner, Harvard University; Kosuke Imai, Harvard University; Zhichao Jiang, University of Massachusetts Amherst
10:55 AM
On Identification of Optimal Dynamic Treatment Regimes: A Proximal Causal Inference Approach
Eric J Tchetgen Tchetgen, University of Pennsylvania
11:15 AM
Confounding-Robust Policy Evaluation in Infinite-Horizon Reinforcement Learning
Angela Zhou, UC Berkeley ; Nathan Kallus, Cornell University
11:35 AM
Off-Policy Evaluation in Partially Observed Markov Decision Processes
Stefan Wager, Stanford University ; Yuchen Hu, Stanford
11:55 AM
Discussant: Qingyuan Zhao, University of Cambridge
12:15 PM
Floor Discussion
552 * !
Thu, 8/11/2022,
10:30 AM -
12:20 PM
CC-152B
State of the Science in Patient-Focused Drug Development with Statistics Leading Innovation: Where Have We Been, and Where Are We Going? — Topic Contributed Panel
Biopharmaceutical Section , Health Policy Statistics Section, Biometrics Section
Organizer(s): Joseph C. Cappelleri, Pfizer Inc; Jessica Roydhouse, Menzies Institute for Medical Research, University of Tasmania
Chair(s): Flora Mulkey, FDA
10:35 AM
State of the Science in Patient-Focused Drug Development with Statistics Leading Innovation: Where Have We Been, and Where Are We Going?
Panelists:
Joseph C. Cappelleri, Pfizer Inc
Mallorie Fiero, US Food and Drug Administration
Shing M Lee, Columbia University
Jessica Roydhouse, Menzies Institute for Medical Research, University of Tasmania
12:10 PM
Floor Discussion