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Activity Number:
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463
- Recent Innovations in Method Developments for Risk-Based Screening and Health Policy Modeling for Cancer
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Type:
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Invited
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Date/Time:
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Wednesday, August 10, 2022 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Risk Analysis
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Abstract #320679
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Title:
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Incorporating Polygenic Risk Scores into Health Screening
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Author(s):
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John Witte*
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Companies:
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Stanford University
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Keywords:
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Genetics;
Cancer;
Screeninig
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Abstract:
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Polygenic risk scores (PRS) provide a promising avenue for incorporating genetic information into cancer prediction and health screening. PRS provide valuable information beyond known non-genetic risk factors for cancer. But PRS are limited in their transferability across different ancestral populations. Most PRS have been developed in European ancestry populations and can have poor predictive performance when applied to non-European individuals. Inaccurate assessment of individuals at high risk of cancer using existing PRS may further exacerbate health disparities. Current efforts are increasing population representation in the development of PRS. One may also help address this issue by developing statistical methods for constructing more accurate PRS across diverse populations. Here we consider how PRS may be improved by incorporating ancestral information and population-specific linkage disequilibrium to refine cancer association signals. We also evaluate whether PRS effects baseline cancer susceptibility or modifies the risk associated with other non-genetic factors. This will allow for improved characterization of the impact of PRS and other factors on cancer screening.
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Authors who are presenting talks have a * after their name.
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