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415 Thu, 8/12/2021, 2:00 PM - 3:50 PM Virtual
Recent advancements in the analysis of large-scale GWAS — Contributed Speed
Section on Statistics in Genomics and Genetics
Chair(s): Zhengqing Ouyang, University of Massachusetts, Amherst
2:05 PM New Selection Probability Computation to Identify Pleiotropic Variants Associated with Both Quantitative and Qualitative Traits
Kipoong Kim, Pusan National University; Hokeun Sun, Pusan National University
2:10 PM Bayestrat: Population Stratification Correction Using Bayesian Shrinkage Priors for Genetic Association Studies
Zilu Liu, The Ohio State University; Asuman Seda Turkmen, The Ohio State University; Shili Lin, The Ohio State University
2:15 PM An Adaptive Multivariate Kernel-Based Test for Association with Multiple Quantitative Traits in High-Dimensional Data
Tao He, San Francisco State University; Brian Neal, San Francisco State University
2:20 PM A Statistical Perspective on Baseline Adjustment in Pharmacogenomic Genome-Wide Association Studies of Quantitative Change
Judong Shen, Merck & Co. Inc.; Hong Zhang, Merck & Co., Inc.; Aparna Chhibber, BMS; Peter M. Shaw, Merck & Co. Inc.; Devan V Mehrotra, Merck & Co., Inc.
2:25 PM Aggregating Across Genes and Cancers in Mendelian Risk Prediction Modeling
Jane W. Liang, Harvard T.H. Chan School of Public Health; Giovanni Parmigiani, Harvard University; Danielle Braun, Harvard T.H. Chan School of Public Health, Dana-Farber Cancer Institute
2:30 PM A Unified Approach to Robust Inference for Genetic Covariance
2:35 PM Probabilistic Models of Natural Selection in the Human Genome
Lauren Sugden, Duquesne University
2:40 PM Knowledge Transfer with False Negative Control Improves the Accuracy of Polygenic Prediction
Yifei Hu, North Carolina State University; Xinge Jessie Jeng, North Carolina State University
2:45 PM Testing Causality of Variants Using Summary Association Statistics
Donghyung Lee, Miami University
2:50 PM RAREsim: A Simulation Method for Very Rare Genetic Variants
Megan Null, The College of Idaho; Josée Dupuis, Boston University; Christopher R Gignoux, University of Colorado Anschutz Medical Campus; Audrey E Hendricks, University of Colorado Denver
3:00 PM Hardy-Weinberg Equilibrium Test Accounting for Population Structure and Relatedness
Derek Shyr, Harvard T.H. Chan School of Public Health; Rounak Dey, Harvard T.H. Chan School of Public Health; Xihong Lin, Harvard T.H. Chan School of Public Health
3:05 PM '… You Built a Time Machine ... Out of a DeLorean?!' Integrating Past, Present, and Future Studies of Complex Disease in Rodent Populations Using Multi-Trait Meta-Analyses
Robyn L Ball, The Jackson Laboratory; Vivek M Philip, The Jackson Laboratory; Jake Emerson, The Jackson Laboratory; Molly Bogue, The Jackson Laboratory; Elissa J Chesler, The Jackson Laboratory
3:10 PM Nonparametric Bounds in Two-Sample Summary-Data Mendelian Randomization: Some Cautionary Tales for Practice
Ralph Møller Trane, University of Wisconsin--Madison; Hyunseung Kang, University of Wisconsin-Madison
3:15 PM Benchmarking Gene Set Analysis Methods: Working with Individual-Level Data from the Full Sample, or a Clever Way to Combine Summary Statistics?
Olga Vsevolozhskaya, University of Kentucky; Xiaoran Tong, NIEHS/NIH; Dmitri .V Zaykin, NIEHS
3:20 PM A Multi-Tissue, Multi-Trait Model for Omics Data
Samantha Lent, Boston University; Ching-Ti Liu, Boston University; Marie-France Hivert, Harvard Medical School; Josée Dupuis, Boston University
3:25 PM GWAS.BAYES: Bayesian stochastic search for GWAS analysis
Jacob Williams, Virginia Polytechnic Institute and State University; Marco May Ferreira, Virginia Tech Department of Statistics; Tieming Ji, University of Missouri
3:30 PM Evaluation of Rare Variant Association Methods When Incorporating External Controls
Jessica Murphy, University of Colorado Denver; Megan Null, The College of Idaho; Christopher R Gignoux, University of Colorado Anschutz Medical Campus; Audrey E Hendricks, University of Colorado Denver
3:35 PM Using Method of Moments Variance Components Estimation for Scalable Genetic Linkage Analysis in Population Cohorts
Gregory JM Zajac, University of Michigan; Goncalo R Abecasis, University of Michigan
3:40 PM Summix: A Method for Detecting and Adjusting for Population Structure in Genetic Summary Data
Ian S. Arriaga-MacKenzie, University of Colorado Denver; Gregory Matesi, University of Colorado Denver; Samuel Chen, University of Colorado Denver; Alexandria Ronco, University of Colorado Denver; Katie M. Marker, University of Colorado Anschutz Medical Campus; Jordan R. Hall, University of Colorado Denver; Ryan Scherenberg, University of Colorado Denver; Mobin Khajeh-Sharafabadi, University of Colorado Denver; Yinfei Wu, University of Colorado Denver; Christopher R Gignoux, University of Colorado Anschutz Medical Campus; Megan Null, The College of Idaho; Audrey E Hendricks, University of Colorado Denver
3:45 PM A Fast and Powerful Linear Mixed Model Approach for Genotype-Environment Interaction Tests in Large-Scale GWAS
Wujuan Zhong, Merck & Co., Inc.; Judong Shen, Merck & Co. Inc.