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394 * Tue, 8/5/2014, 2:00 PM - 3:50 PM CC-258A
Innovative Clinical Trial Design and Analysis Methods — Contributed Papers
Biopharmaceutical Section
Chair(s): Mahinda Karunaratne, AbbVie   
2:05 PM Bayesian Predictive Probability Approach for Phase III Success Based on Published Trial Results from Early Development Meichun Ding, GlaxoSmithKline ; Ying Yang, FDA/CDRH
2:20 PM Optimal Design of Dose-Response Studies in Time-To-Event Settings with Random Censoring Xiaoqiang Xue ; Valerii Fedorov, Quintiles
2:35 PM Dichotomization of Continuous Endpoints: Examination of Efficiency Under Departures from Normality Davis Gates, Merck
2:50 PM Sequential Parallel Comparison Design in Major Depressive Disorder Trials Yangchun Du, Alkermes ; Asli Memisoglu, Alkermes ; Marc de Somer, Alkermes ; Randall Marshall, Alkermes ; Richard Leigh-Pemberton, Alkermes ; Bernard Silverman, Alkermes ; Elliot Ehrich, Alkermes ; Fava Maurizio, Massachusetts General Hospital
3:05 PM Testing Multiple Hypotheses in Truncated Group Sequential Experiments Tian Zhao
3:20 PM Designs for Randomized Phase II Clinical Trials with Two Arms: Agent A vs. Agents A Plus B Myron Chang, University of Florida ; Sin-Ho Jung, Duke University ; Meenakshi Devidas, University of Florida
3:35 PM Floor Discussion



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