Abstract Details
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Activity Number:
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394
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Type:
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Contributed
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Date/Time:
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Tuesday, August 5, 2014 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #312611
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View Presentation
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Title:
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Testing Multiple Hypotheses in Truncated Group Sequential Experiments
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Author(s):
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Tian Zhao*+
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Companies:
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Keywords:
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Familywise error rate ;
Group sequential test ;
Holm-Bonferroni procedure ;
Sequential probability ratio test ;
Stopping boundary ;
Stopping time
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Abstract:
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Statistical procedures are developed for the simultaneous testing of multiple hypotheses in group sequential experiments such as group sequential clinical trials. As a result, a decision has to be made on each tested parameter instead of combining all tests into one hypothesis. Further, the maximum number of sampled groups is restricted. Under these conditions, the proposed multiple testing procedure controls the familywise error rate and the familywise power in the strong sense. Following the Holm approach for multiple comparisons, our truncated sequential schemes require uniformly smaller sample sizes than the commonly used Bonferroni procedure.
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Authors who are presenting talks have a * after their name.
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