Abstract Details
Activity Number:
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394
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Type:
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Contributed
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Date/Time:
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Tuesday, August 5, 2014 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #311211
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Title:
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Optimal Design of Dose-Response Studies in Time-To-Event Settings with Random Censoring
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Author(s):
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Xiaoqiang Xue*+ and Valerii Fedorov
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Companies:
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and Quintiles
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Keywords:
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Elemental Fisher Information Matrices ;
Random Censoring ;
D-optimal ;
Time-to-Event
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Abstract:
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In event-driven clinical trials, an observational window (time interval during which a subject is under observation) is defined by the difference of two moments: right censoring time and patient arrival time. Often arrival time is assumed to be random and the right censoring can be either fixed (the data of the trial termination is a fixed priori) or random (the trial stops when either a given number of patients enrolled or a given number of events accrued). We derived elemental Fisher information matrices for a few scenarios and compute the respective D-optimal designs.
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Authors who are presenting talks have a * after their name.
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