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Every field has data. We use data to discover new knowledge, to interpret the world, to make decisions, and even to predict the future. The recent convergence of big data, cloud computing, and novel machine learning algorithms and statistical methods is causing an explosive interest in data science and its applicability to all fields. This convergence has already enabled the automation of some tasks that better human performance. The novel capabilities we derive from data science will drive our cars, treat disease, and keep us safe. At the same time, such capabilities risk leading to biased, inappropriate, or unintended action. The design of data science solutions requires both excellence in the fundamentals of the field and expertise to develop applications which meet human challenges without creating even greater risk. The Data Science Institute at Columbia University promotes “Data for Good”: using data to address societal challenges and bringing humanistic perspectives as—not after—new science and technology is invented. Started in 2012, the Institute is now a university-level institute representing over 350 affiliated faculty from 16 different schools and institutes across campus. Data science literally touches every corner of the university. In this talk, I will present the mission of the Institute and highlights of our educational and research activities—all with the aim of ensuring the responsible use of data to benefit society.