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Xuemao Zhang

East Stroudsburg University



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230 – Longitudinal Data Analysis

Clustered Binomial Data Analysis by Modified Generalized Estimating Equations

Sponsor: Biometrics Section
Keywords: Clustered binomial data, Extra-binomial variation, Generalized estimating equations, Variance function

Xuemao Zhang

East Stroudsburg University

Extra-binomial variation in clustered binomial data is frequently observed in biomedical and observational studies. The usual generalized estimating equations (GEE) method treats the extra-binomial parameter as a constant across all clusters. In this paper, a two-parameter variance function modeling the extraneous variance is proposed to account for heterogeneity among clusters. The new approach allows modeling the extra-binomial variation as a function of the mean and binomial size.

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