eventscribe

The eventScribe Educational Program Planner system gives you access to information on sessions, special events, and the conference venue. Take a look at hotel maps to familiarize yourself with the venue, read biographies of our plenary speakers, and download handouts and resources for your sessions.

close this panel
‹‹ Go Back

Wencan Zhang

Takeda Development Center



‹‹ Go Back

Lin Li

BioStat Solutions



‹‹ Go Back

Pingye Zhang

Merck



‹‹ Go Back

Yonghong Zhu

Takeda Development Center



‹‹ Go Back

Ling Wang

Takeda Development Center



‹‹ Go Back

Ray Liu

Takeda Development Center



‹‹ Go Back

Please enter your access key

The asset you are trying to access is locked for premium users. Please enter your access key to unlock.


Email This Presentation:

From:

To:

Subject:

Body:

←Back IconGems-Print

660 – Biomarkers in Clinical Research and Development

Theoretical and Practical Considerations in Estimation of Heritability on Drug Response from Whole Genome and Molecular Signature SNPs

Sponsor: Biopharmaceutical Section
Keywords: genomic heritability, estimation bias, h2 for molecular signature, discovery and validation, treatment and PLA arm

Wencan Zhang

Takeda Development Center

Lin Li

BioStat Solutions

Pingye Zhang

Merck

Yonghong Zhu

Takeda Development Center

Ling Wang

Takeda Development Center

Ray Liu

Takeda Development Center

We estimated heritability (h2) on drug response with SNP data. If we define the true portion of available SNPs on variance explained (VE) as h2M and then the SNPs potentially can explain all the genetic variation in the trait (h2M < = h2 ). The VE by genome-wide significant (GWS) SNPs (h2GWS) may satisfy h2GWS 0.01. Subsequently, only SNPs with non-zero parameter estimates will be used in a 'molecular signature (MS)'. Then VE by MS (h2MS) may be even smaller than h2GWS i.e. h2MS < h2GWS

"eventScribe", the eventScribe logo, "CadmiumCD", and the CadmiumCD logo are trademarks of CadmiumCD LLC, and may not be copied, imitated or used, in whole or in part, without prior written permission from CadmiumCD. The appearance of these proceedings, customized graphics that are unique to these proceedings, and customized scripts are the service mark, trademark and/or trade dress of CadmiumCD and may not be copied, imitated or used, in whole or in part, without prior written notification. All other trademarks, slogans, company names or logos are the property of their respective owners. Reference to any products, services, processes or other information, by trade name, trademark, manufacturer, owner, or otherwise does not constitute or imply endorsement, sponsorship, or recommendation thereof by CadmiumCD.

As a user you may provide CadmiumCD with feedback. Any ideas or suggestions you provide through any feedback mechanisms on these proceedings may be used by CadmiumCD, at our sole discretion, including future modifications to the eventScribe product. You hereby grant to CadmiumCD and our assigns a perpetual, worldwide, fully transferable, sublicensable, irrevocable, royalty free license to use, reproduce, modify, create derivative works from, distribute, and display the feedback in any manner and for any purpose.

© 2017 CadmiumCD