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660 – Biomarkers in Clinical Research and Development
Theoretical and Practical Considerations in Estimation of Heritability on Drug Response from Whole Genome and Molecular Signature SNPs
Wencan Zhang
Takeda Development Center
Lin Li
BioStat Solutions
Pingye Zhang
Merck
Yonghong Zhu
Takeda Development Center
Ling Wang
Takeda Development Center
Ray Liu
Takeda Development Center
We estimated heritability (h2) on drug response with SNP data. If we define the true portion of available SNPs on variance explained (VE) as h2M and then the SNPs potentially can explain all the genetic variation in the trait (h2M < = h2 ). The VE by genome-wide significant (GWS) SNPs (h2GWS) may satisfy h2GWS