‹‹ Go Back

Chul Ahn

Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration



‹‹ Go Back

Mourad Atlas

Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration



‹‹ Go Back

Please enter your access key

The asset you are trying to access is locked for premium users. Please enter your access key to unlock.


Email This Presentation:

From:

To:

Subject:

Body:

←Back IconGems-Print

44 – Trial Design and Analysis Issues in Medical Devices

Tests for Interaction in Clinical Studies

Sponsor: Section on Medical Devices and Diagnostics
Keywords: interaction, quantitative, qualitative, power, effect size

Chul Ahn

Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration

Mourad Atlas

Division of Biostatistics, Center for Devices and Radiological Health, Food and Drug Administration

Tests for interaction are used in clinical trials to find a treatment effect that differs by subgroup. In this paper, some of the statistical issues surrounding interaction tests will be discussed. It will include the subgroup-specific test, quantitative and qualitative interaction, and statistical power. Regarding statistical power on interaction test, we will discuss the misconception that there is always less statistical power for interactions than main effects. We will also discuss the misconception about the interpretability of main effects when there is an interaction.

"eventScribe", the eventScribe logo, "CadmiumCD", and the CadmiumCD logo are trademarks of CadmiumCD LLC, and may not be copied, imitated or used, in whole or in part, without prior written permission from CadmiumCD. The appearance of these proceedings, customized graphics that are unique to these proceedings, and customized scripts are the service mark, trademark and/or trade dress of CadmiumCD and may not be copied, imitated or used, in whole or in part, without prior written notification. All other trademarks, slogans, company names or logos are the property of their respective owners. Reference to any products, services, processes or other information, by trade name, trademark, manufacturer, owner, or otherwise does not constitute or imply endorsement, sponsorship, or recommendation thereof by CadmiumCD.

As a user you may provide CadmiumCD with feedback. Any ideas or suggestions you provide through any feedback mechanisms on these proceedings may be used by CadmiumCD, at our sole discretion, including future modifications to the eventScribe product. You hereby grant to CadmiumCD and our assigns a perpetual, worldwide, fully transferable, sublicensable, irrevocable, royalty free license to use, reproduce, modify, create derivative works from, distribute, and display the feedback in any manner and for any purpose.

© 2016 CadmiumCD