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Md Hamidul Huque

University of Technology



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Howard D. Bondell

North Carolina State University



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Raymond J. Carroll

Texas A&M



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Louise Ryan

University of Technology



231 – Mixed Effect Models for Longitudinal, Functional, and Spatial Data

Spatial Regression with Covariate Measurement Error: A Semiparametric Approach

Sponsor: Biometrics Section
Keywords: Measurement error, spatial correlation, penalized likelihood, splines, thin plate spline regression basis

Md Hamidul Huque

University of Technology

Howard D. Bondell

North Carolina State University

Raymond J. Carroll

Texas A&M

Louise Ryan

University of Technology

Spatial data have become increasingly common in epidemiology and public health research due to the rapid advances in GIS (Geographic Information Systems) technology. In health research, for example, it is common for epidemiologists to incorporate geographically indexed data into their studies. In practice, however, the spatially-defined covariates are often measured with error. The classical measurement error theory is inapplicable in the context of spatial modeling because of the spatial correlation among the observations. The naïve estimator of regression coefficients are attenuated if measurement error is ignored. We proposed a semi parametric regression approach to obtain the bias corrected estimates of the regression parameter and derived the large sample properties of the estimates. We evaluate the performance of the proposed method through simulation studies and illustrate using real examples.

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