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Activity Number: 29 - Statistical Issues Specific to Therapeutic Areas, Power and Sample Size Calculations, and Trial Monitoring
Type: Contributed
Date/Time: Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
Sponsor: Biopharmaceutical Section
Abstract #319031
Title: WITHDRAWN: Comparison of Methods for Adjusting for Crossover in Oncology Trials
Author(s): Jin Zhang
Companies: Merck
Keywords: Crossover; Oncology; Survival
Abstract:

In randomized oncology trials, patients in the control arm are sometimes permitted to switch to receive experimental drug after disease progression. While progression-free survival is not usually impacted by crossover, the treatment effect on overall survival can be highly confounded. The rank-preserving structural failure time (RPSFT) model is one of the most widely used model. In this presentation, we compare the performance of RPSFT and other competing methods for correcting the impact of treatment switching on overall survival.


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