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Activity Number: 208 - Personalized and Precision Medicine
Type: Contributed
Date/Time: Tuesday, August 10, 2021 : 1:30 PM to 3:20 PM
Sponsor: Biometrics Section
Abstract #318198
Title: Constructing Dynamic Treatment Regimes in Presence of Noncompliance
Author(s): Ashkan Ertefaie and Cuong Pham*
Companies: University of Rochester and University of Rochester, Dept of Biostatistics and Computational Biology
Keywords: Dynamic Treatment Regimes; Semiparametric; Causal Inference; Noncompliance; Weighted SVM
Abstract:

Existing literature on constructing optimal regimes often focuses on intention-to-treat analyses that completely ignore the compliance behavior of individuals. Instrumental variable-based methods have also been developed to learn optimal regimes under endogeneity. However, when there are two active treatment arms, the average causal effects of treatments cannot be identified using instrumental variable methods, and thus the existing methods will not be applicable. To fill this gap, we provide a procedure that identifies an optimal regime and the corresponding value function as a function of a vector of sensitivity parameters. We also derive the canonical gradient of the target parameter and propose a multiply robust classification-based estimator of the optimal regime. Our simulations highlight the need for and usefulness of the proposed method in practice.


Authors who are presenting talks have a * after their name.

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