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Activity Number: 24 - Recent Advances in Causal Analyses That Tell the Story of Complex Mediation Mechanisms
Type: Topic-Contributed
Date/Time: Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
Sponsor: Biometrics Section
Abstract #317419
Title: A causal approach to functional mediation analysis with application to a smoking cessation intervention
Author(s): Donna L. Coffman* and John J. Dziak and Yajnaseni Chakraborti and Megan E. Piper
Companies: Temple University and Pennsylvania State University and Temple University and University of Wisconsin - Madison
Keywords: mediation; functional regression; causal inference; smoking cessation

The increase in the use of mobile and wearable devices now allow dense assessment of mediating processes over time. For example, a pharmacological intervention may have an effect on smoking cessation via reductions in withdrawal symptoms. We define and identify the causal (in)direct effects in terms of potential outcomes and present a method for estimating and testing the indirect effect of a randomized treatment on a distal (i.e., point end-of-study) binary outcome as mediated by the nonparametric trajectory of an intensively measured longitudinal variable (e.g., from ecological momentary assessment). Coverage of a bootstrap test for the indirect effect is demonstrated via simulation. An empirical example is presented based on predicting one-month smoking abstinence from patterns of craving during the first four weeks of a pharmacological smoking cessation treatment.

Authors who are presenting talks have a * after their name.

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