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Activity Number:
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24
- Recent Advances in Causal Analyses That Tell the Story of Complex Mediation Mechanisms
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Type:
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Topic-Contributed
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Date/Time:
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Sunday, August 8, 2021 : 1:30 PM to 3:20 PM
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Sponsor:
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Biometrics Section
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Abstract #317419
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Title:
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A causal approach to functional mediation analysis with application to a smoking cessation intervention
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Author(s):
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Donna L. Coffman* and John J. Dziak and Yajnaseni Chakraborti and Megan E. Piper
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Companies:
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Temple University and Pennsylvania State University and Temple University and University of Wisconsin - Madison
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Keywords:
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mediation;
functional regression;
causal inference;
smoking cessation
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Abstract:
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The increase in the use of mobile and wearable devices now allow dense assessment of mediating processes over time. For example, a pharmacological intervention may have an effect on smoking cessation via reductions in withdrawal symptoms. We define and identify the causal (in)direct effects in terms of potential outcomes and present a method for estimating and testing the indirect effect of a randomized treatment on a distal (i.e., point end-of-study) binary outcome as mediated by the nonparametric trajectory of an intensively measured longitudinal variable (e.g., from ecological momentary assessment). Coverage of a bootstrap test for the indirect effect is demonstrated via simulation. An empirical example is presented based on predicting one-month smoking abstinence from patterns of craving during the first four weeks of a pharmacological smoking cessation treatment.
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Authors who are presenting talks have a * after their name.
