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Activity Number: 68 - Recent Advances of Causal Inferences in Human Genetics
Type: Invited
Date/Time: Monday, August 9, 2021 : 10:00 AM to 11:50 AM
Sponsor: WNAR
Abstract #316942
Title: Debiased Inference in Mendelian Randomization After Selecting Among High-Dimensional Genetic Instruments
Author(s): Chong Wu and Jingshen Wang*
Companies: Florida State University and UC Berkeley
Keywords: Post selection inference; Instrumental variable

Mendelian randomization has been frequently adopted to conduct causal inference with genetic summary statistics. While strong instruments are frequently selected to increase hypothesis testing power, the impact of instrument selection can not be neglected in practice. In this talk, we shall illustrate how model selection affects the performance of commonly adopted Mendelian randomization approaches include inverse weighting. We also propose some remedies to mitigate selection bias. 

Authors who are presenting talks have a * after their name.

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