575 * !
Thu, 8/6/2020,
3:00 PM -
4:50 PM
Virtual
Trial Design with Subpopulation Heterogeneity: What Is the Role of Real-World Evidence? — Topic Contributed Papers
Biopharmaceutical Section , Biometrics Section, Section on Bayesian Statistical Science
Organizer(s): Brian Hobbs, University of Texas at Austin
Chair(s): Emily Zabor, Cleveland Clinic
3:05 PM
Promise and Challenge of RWE for Drug Development
Lei Nie , FDA ; Ying Yuan, The University of Texas MD Anderson Cancer Center
3:25 PM
Evaluating Off-Label Use of Targeted Cancer Treatments: Generating RWE for Precision Medicine Using CancerLinQ Discovery (CLQD) Data
Elizabeth Garrett-Mayer, American Society of Clinical Oncology ; Melinda Kaltenbaugh, American Society of Clinical Oncology
3:45 PM
Dynamic Borrowing in the Presence of Treatment Effect Heterogeneity
Joseph Koopmeiners, University of Minnesota ; Ales Kotalik, University of Minnesota; David Vock, University of Minnesota
4:05 PM
A Bayesian Adaptive Design for Concurrent Trials Involving Biologically-Related Diseases
Xun Jiang, Amgen
4:25 PM
Basket Trial Design: Challenges and Potential Solutions
Alexander Kaizer, University of Colorado ; Joseph Koopmeiners, University of Minnesota; Nan Chen, University of Texas M.D. Anderson Cancer Center; Brian Hobbs, University of Texas at Austin
4:45 PM
Floor Discussion
