Historically, men diagnosed with Takotsubo Cardiomyopathy (TC) have worse outcomes compared to women. We sought to use the propensity score matching method to identify factors that lead to gender difference in hospital charges, number of procedures performed, and length of stay (LOS). TC encounters in the National Inpatient Sample were propensity matched by combinations of age, number of chronic conditions, number of procedures, and severity of illness. A discharge weight was included in all analyses to account for the complex sample design of the NIS. During 2009-2015, 1,448 men and 9,404 women with secondary TC were identified, corresponding to a national estimate of 7,124 men and 46,163 women. The median hospital charges were $54,655 for men and $45,455 for women. Average procedures performed was 5.2 for men and 4.5 for women. Median LOS was 4.3 days for men and 3.6 days for women. In-hospital mortality was 5.5% in men and 3.3% in women. Applying propensity-matching for age and number of procedures, the difference between men and women for median total charges decreased to $1,658, the LOS difference decreased to 0.3 days, and the mortality difference decreased to 1.3%.