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Activity Number:
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403
- SPAAC Poster Competition
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Type:
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Topic Contributed
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Date/Time:
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Tuesday, July 30, 2019 : 2:00 PM to 3:50 PM
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Sponsor:
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Section on Medical Devices and Diagnostics
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Abstract #301817
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Title:
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Strategies for Pooling in Array Testing Configurations with Multiplex Assays
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Author(s):
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Christopher Bilder* and Joshua Tebbs and Christopher McMahan
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Companies:
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University of Nebraska-Lincoln and University of South Carolina and Clemson University
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Keywords:
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assay;
group testing;
matrix pooling;
pooled testing;
sensitivity;
specificity
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Abstract:
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High volume screening of clinical specimens for infectious diseases is often performed by a process known as group testing. This algorithmic process involves pooling together portions of specimens from separate individuals. Each group formed is tested to detect a human body’s response to infection or the pathogen that leads to disease. Follow-up retesting is performed on those groups that test positively to decode the positive individuals from the negative individuals. One of the most efficient group testing algorithms is array testing. In its simplest form, specimens are tested in a grid-like structure so that groups can be formed by row and by column. Positive-testing rows/columns present clues on which individual specimens to retest. In our presentation, we investigate how one can use multiplex assays (multiple-disease tests) together with individual risk information to increase testing efficiency. We show how particular specimen arrangements within an array can lower the number of retests needed when compared to unordered arrangements.
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Authors who are presenting talks have a * after their name.
