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36 * Sun, 7/29/2012, 2:00 PM - 3:50 PM CC-Room 28E
Innovations in Adaptive Design — Contributed Papers
Biopharmaceutical Section
Chair(s): Chengxing Lu, Novartis
2:05 PM Model Combining in a Covariate-Adjusted Response-Adaptive Design Wei Qian, University of Minnesota ; Yuhong Yang, University of Minnesota
2:20 PM Adaptive Designs for Vaccine Clinical Trials Ghideon Ghebregiorgis, FDA
2:35 PM Novel Adaptive Design for Integrated Development of Therapies with Competitive Challenge Yijie Zhou, Merck ; Ziliang Li, Merck ; Amarjot Kaur, Merck Research Laboratories
2:50 PM Sources of Bias in Adaptive Seamless Phase II/III Designs Jing Zhang, FDA ; Kun He, FDA
3:05 PM Fractional Two-Step Adaptive Randomization Procedure for Delayed Response in Clinical Trials Jiajing Xu, The University of Hong Kong
3:20 PM Optimize Promising Zone in an Adaptive Design for a Confirmatory Study Jung Wook Park, Astellas Pharma Global Development, Inc. ; Xiaosha Sherman Zhang, Astellas Pharma Global Development, Inc. ; Jay Yang, Astellas Pharma Global Development, Inc. ; Chaofeng Charles Liu, Astellas Pharma Global Development, Inc.
3:35 PM Unknown Correlation Coefficient Between a Primary and a Secondary Endpoint in a Two-stage Group Sequential Design Yi Wu ; Ajit C. Tamhane, Northwestern University ; Cyrus R Mehta, Cytel Inc.



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