JSM 2012 Home

JSM 2012 Online Program

The views expressed here are those of the individual authors and not necessarily those of the JSM sponsors, their officers, or their staff.

Online Program Home

Abstract Details

Activity Number: 36
Type: Contributed
Date/Time: Sunday, July 29, 2012 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #304505
Title: Optimize Promising Zone in an Adaptive Design for a Confirmatory Study
Author(s): Jung Wook Park*+ and Xiaosha Sherman Zhang and Jay Yang and Chaofeng Charles Liu
Companies: Astellas Pharma Global Development, Inc. and Astellas Pharma Global Development, Inc. and Astellas Pharma Global Development, Inc. and Astellas Pharma Global Development, Inc.
Address: Three Parkway North, Deerfield, IL, 60015-2548, United States
Keywords: adaptive design ; promising zone ; confirmatory study

In recent years, implementation of optimal adaptive designs for confirmatory clinical trials with the limited budget has been of great interest in the pharmaceutical industry. A popular method is to find a fixed range of conditional power (namely promising zone) that would provide most promising results after sample size adaptation such as Mehta and Pocock (2010)(MP hereafter). In this presentation, we will propose an alternative approach to define a promising zone, which maximizes conditional power increase, and introduce an approximate permutation test to evaluate the performance of the promising zone in terms of relative efficiency, compared to a random adaptation and the MP promising zone adaptation. A simulation study will be presented to show the operating characteristics of the proposed promising zone. Then, we will compare statistical properties between using CHW vs. not using CHW in promising zone based adaptive design.

The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.

Back to the full JSM 2012 program

2012 JSM Online Program Home

For information, contact jsm@amstat.org or phone (888) 231-3473.

If you have questions about the Continuing Education program, please contact the Education Department.