An Analysis of the Survival Aspect of COPDGene

• Activity Number: 573
• Type: Contributed
• Date/Time: Wednesday, August 1, 2012 : 2:00 PM to 3:50 PM
• Sponsor: WNAR
• Author(s): Andre Williams*+ and Russell Bowler and Anna Forssen
• Companies: National Jewish Health and National Jewish Health and National Jewish Health
• Keywords: BODE ; COPDGene ; mortality

Abstract

The BODE score is comprised of (B)ody mass index, airflow (O)bstruction, (D)yspnea score, and (E)xercise capacity measures and is a multifaceted way to evaluate risk of death associated with Chronic Obstructive Pulmonary Disease (COPD). The COPDGene study includes over 10,000 subjects with a large amount of phenotyping and mortality data. Discovering variables that correlate with mortality in the study, as well as evaluating variables that correlate with the BODE score, will give insight into the survival aspect of the data. We will present analysis using simple and multiple survival data analysis, logistic regression, random survival forests and ordinal regression to evaluate mortality risk. The goal of this study is to develop profiles, based on a given set of variables, of patients with COPD who are at high risk. In addition, we want to validate how successful the BODE score is at predicting patient mortality.