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Abstract Details
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Activity Number:
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404
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Type:
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Contributed
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Date/Time:
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Tuesday, July 31, 2012 : 2:00 PM to 3:50 PM
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Sponsor:
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Biopharmaceutical Section
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| Abstract - #305831 |
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Title:
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Bayesian Adaptive Phase II Trial Combining Proof of Concept and Dose-Finding: Comparison of Potential Models
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Author(s):
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Katherine Kacena and Robert Noble*+ and Ping Chen and Richard A Brigandi
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Companies:
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Aptiv Solutions and Aptiv Solutions and Aptiv Solutions and GlaxoSmithKline
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Address:
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, , ,
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Keywords:
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Bayesian ;
adaptive ;
dose-response ;
dose-finding ;
Phase II ;
proof of concept
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Abstract:
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A case study of a Phase II Bayesian adaptive design will be presented. Characteristics of this binary endpoint study include: (1) combination of proof of concept and dose-finding, and (2) potential for the dose-response curve to have a reflection point. Piecewise logistic and other models including e-max models are evaluated and compared as potential response curves.
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Authors who are presenting talks have a * after their name.
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