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404 * Tue, 7/31/2012, 2:00 PM - 3:50 PM CC-Room 25A
Adaptive Designs with Applications in Phase I/II Trials — Contributed Papers
Biopharmaceutical Section
Chair(s): Annpey Pong, Merck
2:05 PM Bayesian Adaptive Phase II Trial Combining Proof of Concept and Dose-Finding: Comparison of Potential Models — Katherine Kacena, Aptiv Solutions ; Robert Noble, Aptiv Solutions ; Ping Chen, Aptiv Solutions ; Richard A Brigandi, GlaxoSmithKline
2:20 PM A Phase I Bayesian Adaptive Design to Simultaneously Optimize Dose and Schedule Among and Within Patients Jin Zhang, University of Michigan ; Thomas M Braun, University of Michigan
2:35 PM A Bayesian Phase I/II Trial Design with Delayed Outcomes Ick Hoon Jin, MD Anderson Cancer Center ; Ying Yuan, MD Anderson Cancer Center
2:50 PM A Phase I Trial Design for Incorporating Efficacy Outcomes That are Conditional Upon Absence of Dose-Limiting Toxicities Shan Kang, University of Michigan ; Thomas M Braun, University of Michigan ; Jeremy Michael George Taylor, University of Michigan
3:05 PM Two-stage futility analysis in phase III adaptive trials with time-to-event endpoint Xiaoyun (Nicole) Li, Merck & Co. ; Cong Chen, Merck
3:20 PM Web-EWOC: Interactive Web Tool for Designing and Conducting Dose-Finding Trials in Cancer Dror Berel, Cedars Sinai Medical Center ; Andre Rogatko, Cedars Sinai Medical Center ; Shao-Chi Huang, Cedars Sinai Medical Center ; Haibin Wang, Cedars Sinai Medical Center ; Galen Cook-Wiens, Cedars Sinai Medical Center ; Mourad Tighiouart, Cedars Sinai Medical Center
3:35 PM Phase III Design for Continuous Responses with an Adaptive Tuning Parameter Aleksandra Stein, University of Nebraska ; Aleksandra Stein, University of Nebraska



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