JSM 2005 - Toronto

Abstract #303803

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Legend: = Applied Session, = Theme Session, = Presenter
Activity Number: 522
Type: Contributed
Date/Time: Thursday, August 11, 2005 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract - #303803
Title: Optimal Designs in Stability Studies
Author(s): Xu Yan*+ and Samad Hedayat
Companies: U.S. Food and Drug Administration and University of Illinois, Chicago
Address: 545 Elmcroft Blvd, Rockville, MD, 20850, United States
Keywords: Shelf life ; Optimality criterion ; Matrix design ; Bracketing design ; Power ; Information matrix
Abstract:

In this paper, we propose new optimality criteria for stability studies and investigate the related optimal designs. For each optimality criterion, we identify optimal designs within a class of competing designs. Finally, we discuss the property of the optimal designs with respect to detecting slope differences.

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Revised March 2005