JSM 2004 - Toronto

Abstract #301199

This is the preliminary program for the 2004 Joint Statistical Meetings in Toronto, Canada. Currently included in this program is the "technical" program, schedule of invited, topic contributed, regular contributed and poster sessions; Continuing Education courses (August 7-10, 2004); and Committee and Business Meetings. This on-line program will be updated frequently to reflect the most current revisions.

To View the Program:
You may choose to view all activities of the program or just parts of it at any one time. All activities are arranged by date and time.

The views expressed here are those of the individual authors
and not necessarily those of the ASA or its board, officers, or staff.

Back to main JSM 2004 Program page
Activity Number: 200
Type: Contributed
Date/Time: Tuesday, August 10, 2004 : 9:00 AM to 10:50 AM
Sponsor: General Methodology
Abstract - #301199
Title: Imprinting Detection by Extending a Regression-based QTL Method: An Extensive Simulation Study
Author(s): Lei Lei*+ and Olga Gorlova
Companies: University of Texas M.D. Anderson Cancer Center and University of Texas MD Anderson Cancer Center
Address: Dept of Biological Sciences, Lubbock, TX, 79409-3131,
Keywords: linkage analysis ; imprinting ; regression-based QTL method ; simulation
Abstract:

We extended Sham et al.'s regression-based quantitative-trait linkage analysis method by regressing overall, paternal and maternal IBD sharing on traits separately. We also extended the method to calculate an imprinting index statistics. We suggest using a panel of statistics to detect imprinting, which includes overall T, both parental T statistics and the D index. After an extensive simulation study, we found that when using empirical percentiles (1) the method is extremely powerful by showing clear imprinting patterns with correct Type I error rate for the nonimprinted IBD, although the test of imprinting is too conservative; (2) the method is not sensitive to misspecification of heritability; (3) with low genetic heritability, power of the method decreases dramatically but the panel still performs well; (4) misspecification of the mean of trait decreases the power dramatically; and (5) missing parental marker increases Type I error of both linkage and imprinting test and decreases the power of imprinting test. The method is applied to a data set with six body size related measures and 23 loci on chromosome seven for 255 nuclear families. Linkage and imprinting are both detected.

  • The address information is for the authors that have a + after their name.
  • Authors who are presenting talks have a * after their name.

Back to the full JSM 2004 program

JSM 2004 For information, contact jsm@amstat.org or phone (888) 231-3473. If you have questions about the Continuing Education program, please contact the Education Department.
Revised March 2004