JSM 2004 - Toronto

Abstract #300560

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Activity Number: 423
Type: Topic Contributed
Date/Time: Thursday, August 12, 2004 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract - #300560
Title: Sample Size Calculation for Simulation-based Multiple Testing Procedures
Author(s): Heejung Bang*+ and Sin-Ho Jung and Stephen George
Companies: University of North Carolina and Duke University and Duke University
Address: 137 E. Franklin St. Suite 400, Chapel Hill, NC, 27599,
Keywords: Bonferroni test ; multiple outcomes ; power ; quality of life ; sample size ; simulation
Abstract:

We present a simple method to calculate sample size and power using a simulation-based multiple testing procedure which gives a sharper critical value than the standard Bonferroni method. The method is especially useful when several highly correlated test statistics are involved in a multiple testing procedure. The formula for sample size calculation will be useful in designing clinical trials with multiple endpoints or correlated outcomes. We illustrate our method with a quality-of-life study for patients with early stage prostate cancer. Our method can also be used for comparing multiple independent groups.

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Revised March 2004