JSM 2004 - Toronto

Abstract #300200

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Activity Number: 66
Type: Invited
Date/Time: Monday, August 9, 2004 : 8:30 AM to 10:20 AM
Sponsor: Section on Risk Analysis
Abstract - #300200
Title: Modeling the Impact of HIV-1 Vaccines in an Era of HAART and Potential Change in Risk Behavior
Author(s): Wasima Rida*+ and Sonja Sandberg
Companies: Statistics Collaborative, Inc. and Framingham State University
Address: , , ,
Keywords: AIDS ; epidemic modeling ; HIV vaccines ; vaccine efficacy
Abstract:

Using a system of differential equations, we explore the potential effects of HIV-1 vaccination on the prevalence of HIV and AIDS in a population of men who have sex with men. Biological effects of vaccination include reduced susceptibility to infection, delay in progression to AIDS, and reduced infectiousness of vaccine recipients who become infected. Duration of protection and the potential of HIV exposure or re-vaccination to boost immunologic responses are considered. Behavioral effects of vaccination include potential change in the number or duration of sexual partnerships among vaccinees and non-vaccinees as well as the use of HAART following HIV infection. Special attention is given to vaccines with low or moderate efficacy as these vaccines may represent first generation products considered for licensure.

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