JSM 2004 - Toronto

Abstract #301775

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Activity Number: 409
Type: Contributed
Date/Time: Thursday, August 12, 2004 : 8:30 AM to 10:20 AM
Sponsor: Section on Health Policy Statistics
Abstract - #301775
Title: A Comparison of Methods Used for Constructing Confidence Intervals for Cost-effectiveness Ratio
Author(s): Ming-Yu Fan*+ and Xiao-Hua A. Zhou
Companies: University of Washington and University of Washington
Address: 1959 NE Pacific St., Seattle, WA, 98195-6490,
Keywords: cost-effectiveness ; simulation ; bootstrap
Abstract:

The incremental cost-effectiveness ratio (ICER) has been well accepted as a measure for cost-effectiveness in health sciences. Due to the skewed distribution nature for costs and estimated ICER, however, constructing an appropriate confidence interval for ICER is a challenge. Many methods have been proposed, yet systematic comparisons are rarely found in the literature. Also, there has been a conflict recommendation on which method is better. Polsky et al. (1997) and Briggs et al. (1999) have performed simulation studies to compare four and eight methods, respectively. However, their simulations only considered a selected number of available approaches and a very limited type of distributions for cost and effectiveness outcomes. We have conducted an extensive simulation to compare most commonly used as well as some new methods by generating different types of skewed samples. The methods are also compared across wide range of parameters to incorporate the variation observed in real data. The result suggests that bootstrap-t method is consistently better than other bootstrap or normal-theory-based methods for non-normal data. For normal data, all methods yield desirable result.


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