Abstract #301279

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JSM 2003 Abstract #301279
Activity Number: 335
Type: Contributed
Date/Time: Wednesday, August 6, 2003 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract - #301279
Title: A Model-Based Bayesian Transmission Disequilibrium Test for Linkage
Author(s): Varghese George*+ and Sanjay Shete
Companies: University of Alabama, Birmingham and University of Texas M.D. Anderson Cancer Center
Address: 1530 3rd Ave. S-327 Ryals Pub Hlth Bldg., Birmingham, AL, 35294-0001,
Keywords: Bayesian methods ; linkage ; association ; TDT
Abstract:

The transmission disequilibrium test (TDT) is a powerful method for detecting a disease locus in linkage and linkage disequilibrium with a marker. In this presentation we developed a Bayesian approach for testing for linkage in the presence of allelic association when mode of inheritance (that is, how the disease is passed from one generation to the next) is known. We compare the proposed Bayesian TDT with the usual TDT. We found that the proposed method is more powerful and that the estimated values of recombination fraction are more accurate. We also evaluated robustness of our method when mode of inheritance is not correctly specified. We also evaluate effect of choice of priors on estimation of recombination fraction.

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