Abstract #300856

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JSM 2003 Abstract #300856
Activity Number: 50
Type: Contributed
Date/Time: Sunday, August 3, 2003 : 4:00 PM to 5:50 PM
Sponsor: Section on Quality & Productivity
Abstract - #300856
Title: Defining and Testing Equivalence in Industrial Settings
Author(s): Jorge Quiroz*+
Companies: Wyeth Research
Address: 401 N. Middletown Rd., Pearl River, NY, 10965-1215,
Keywords: equivalence studies ; technology transfer ; confidence intervals ; variance components
Abstract:

A common practice in industrial settings is to determine the equivalence between two methods or two laboratories. Average equivalence is the preferred method. Average equivalence focuses only on the comparison of the means. However, it may also be of interest to compare the variabilities. We propose an equivalence method that considers the means and variabilities when comparing two methods or two laboratories. We develop bounds for conducting statistical tests using the proposed equivalence criterion. Simulation is conducted to study the performance of the bounds. The criteria are the ability to maintain the stated confidence level as well as the stated test size, and the simulated power of the tests using these bounds. Bounds that perform well at small sample size are also desirable.

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