JSM Activity #233


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Activity ID:  233
Title
* ! Statistical Methods in Pharmacogenomics
Date / Time / Room Sponsor Type
08/13/2002
2:00 PM - 3:50 PM
Room: H-East Ballroom
Biometrics Section*, Biopharmaceutical Section*, ENAR Invited
Organizer: David Allison, University of Alabama, Birmingham
Chair: Bernard Gorman, Nassau Community College/SUNY and Hofstra University
Discussant: 3:20 PM - David Redden, University of Alabama, Birmingham    
Floor Discussion 3:40 PM
Description

In what has been called the 'post-genomic era,' clearly one of the greatest challenges and opportunities facing scientists is how to make reliable, effective, and, hopefully, optimal use of the massive amount of data available. The input of creative statisticians to this process is critical. As strongly as anywhere, these opportunities and challenges are manifest in the area of pharmacogenomics. Pharmacogenomics can be defined as the study of genetic factors that may mediate or moderate the phenotypic effects of drugs. Recently, a variety of new tools, both physical and statistical, have become available making pharmacogenomics an area of rapid and exciting developments. In this symposium, we hope to give an overview of this area of investigation by highlighting several different issues and challenges in pharmacogenomics research and the statistical methods available and still requiring development to meet these challenges.
  300087  By:  David  Allison 2:05 PM 08/13/2002
Mixture Model and Empirical Bayes Analysis of Microarray Gene Expression Studies for Drug Target Identification

  300088  By:  Gary L. Gadbury 2:30 PM 08/13/2002
Individual Treatment Variability in Clinical Experiments and the Implications for Genetic Studies

  300089  By:  Robert  Elston 2:55 PM 08/13/2002
The Study of Candidate Genes in Drug Trials: Sample Size Considerations

JSM 2002

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Revised March 2002