Abstract #300089

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JSM 2002 Abstract #300089
Activity Number: 233
Type: Invited
Date/Time: Tuesday, August 13, 2002 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section*
Abstract - #300089
Title: The Study of Candidate Genes in Drug Trials: Sample Size Considerations
Author(s): Robert Elston*+
Affiliation(s): Case Western Reserve University
Address: MetroHealth Medical Center, 2500 MetroHealth Drive, Cleveland, Ohio, 44109-1998, USA
Keywords: pharmacogenomics ; pharmacogenetics ; power analysis ; sample size
Abstract:

With discovery of an increasing number of candidate genes that may affect inter-individual variability in response to drugs, the design of drug trials that incorporate their study has become relevant. We discuss the determination of sample size for such studies when the number of tests to perform is given, or, alternatively, the number of tests to perform when the sample size is given. In many cases, a uniformly most powerful test does not exist and normal approximations are not sufficiently accurate to determine sample size. We discuss briefly various tests of interes, and we give simple examples to illustrate some of the problems that arise.

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Revised March 2002