Abstract #301106

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JSM 2002 Abstract #301106
Activity Number: 311
Type: Contributed
Date/Time: Wednesday, August 14, 2002 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology*
Abstract - #301106
Title: The Optimal Strategy in Designing a Case-Control Study
Author(s): Peng Liu*+
Affiliation(s): Food and Drug Administration
Address: 5100 Paint Branch Parkway, College Park, Maryland, 20740, USA
Keywords: Retrospective study ; Sample size ; Equivalent sample size ; Maximize power ; Minimize cost ; Unequal-size design
Abstract:

The nonlinear programming technique is adopted to determine the best design strategy for treating a non-pairwise matching case-control study with constraints. The graphical solution technique is presented for insight into the mechanisms of the optimization process. The optimization procedure can be summarized into four steps: 1.) graph the region of each constraint expressed by an inequality equation; 2.) determine the feasible solution region satisfied by all the constraints; 3.) graph a family of objective functions; and 4.) determine the optimum solution by the intersection between the objective function and the boundary of the feasible solution region or the critical point.

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Revised March 2002