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All Times EDT

Thursday, September 24
Thu, Sep 24, 1:30 PM - 2:45 PM
Virtual
Historical Data Borrowing in Clinical Trials

Leveraging Historical Information: Methods and Applications (301181)

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*Ming-Hui Chen, University of Connecticut 

Keywords: Conditional Borrowing, Data compatibility, Dissonance, Information gain, Power Prior

In this presentation, I will provide a brief overview of the development of power prior for leveraging historical data. Then, I will introduce a newly developed Bayesian measure to quantify the amount of information provided by the data based on the comparison of the prior and the posterior distributions. Finally, I will present the methodology for Bayesian design via conditional borrowing. Several case studies will be presented to demonstrate usefulness of these methodologies in real applications.