This is the program for the 2010 Joint Statistical Meetings in Vancouver, British Columbia.
Abstract Details
Activity Number:
|
584
|
Type:
|
Contributed
|
Date/Time:
|
Wednesday, August 4, 2010 : 2:00 PM to 3:50 PM
|
Sponsor:
|
Biopharmaceutical Section
|
Abstract - #308577 |
Title:
|
Statistical and Clinical Characteristics of Composite Endpoint in Clinical Studies
|
Author(s):
|
Jeng Mah*+
|
Companies:
|
Regulatory and Clinical Research Institute, Inc.
|
Address:
|
5353 Wayzata Boulevard, suite 505, Minneapolis, MN, 55416,
|
Keywords:
|
composite endpoint ;
parameterization ;
estimation ;
hypothesis testing ;
prediction
|
Abstract:
|
A composite endpoint is a group of measurements which together provide a single-dimensioned evaluation of a specific clinical outcome. Because of their flexibility and convenience, composite endpoints have become widely used in clinical studies, especially for medical devices. A composite endpoint typically includes multiple standard measurements and a decision rule to combine these into a final binary result; however, the implications and consequences of this simplification are sometimes not carefully considered before directly applying standard statistical analyses and hypothesis testing.
This paper examines the statistical properties of a typical composite endpoint, such as distribution, parameterization, and estimation, and their impacts on clinical interrelation of a composite endpoint. Simulated data are used to verify and illustrate derived results.
|
The address information is for the authors that have a + after their name.
Authors who are presenting talks have a * after their name.
Back to the full JSM 2010 program
|
2010 JSM Online Program Home
For information, contact jsm@amstat.org or phone (888) 231-3473.
If you have questions about the Continuing Education program, please contact the Education Department.