JSM 2004 - Toronto

Abstract #300158

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Activity Number: 31
Type: Invited
Date/Time: Sunday, August 8, 2004 : 4:00 PM to 5:50 PM
Sponsor: Cmte on Women in Statistics
Abstract - #300158
Title: Assessing Tumors and Patient Prognosis in a Context of Tumor Heterogeneity: An Example with Noninvasive Breast Cancer
Author(s): Judy-Anne Chapman*+
Companies: Henrietta Banting Breast Centre
Address: University of Toronto and Dept. of Statistics and Actuarial Science, University of Waterloo, Kitchener, ON, N2M 3A1, Canada
Keywords: genomics ; breast cancer ; sample size ; image analysis ; heterogeneity
Abstract:

The assessment of tumors is increasingly performed with very small amounts of tissue while there has been a proliferation of the number of biomarkers being assessed. The Kananaskis working group on quantitative methods in tumor heterogeneity established a research framework for assessing genetic markers of tumor progression, in the context of intratumor heterogeneity. The tenets of this framework will be outlined. A case study will be described for the heterogeneous context of noninvasive breast cancer, breast ductal carcinoma in situ (DCIS). Computer image analysis of nuclei within 10 replicates (five ducts in each of two fields) indicated significant heterogeneity within ducts, between ducts, and between fields. This heterogeneity impacted prognostic investigations. There are sample size implications in the domain of number of cells and area of tumor utilized for investigations by image analysis and microdissection.

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Revised March 2004