Using Meta-Analysis on Clinical Data to Refute a Common Misconception About Toothpaste (306590)Aaron Biesbrock, Procter & Gamble
Joe DiGennaro, Procter & Gamble
Tao He, Procter & Gamble
Dave Ramsey, Procter & Gamble
*Yuanshu Zou, Procter & Gamble
Keywords: Stannous fluoride, Meta-analysis
“All fluoride toothpastes are the same” is a common misconception in oral health. Seventy-one randomized clinical studies with seven thousand subjects across eight countries worldwide were included in this research. Meta-analyses using inverse variance method with both fixed and random-effects models were done to evaluate bioavailable stannous fluoride toothpastes across various benefit areas: gingivitis, plaque, sensitivity and erosion. The results demonstrate the superiority of bioavailable stannous fluoride toothpastes over toothpastes containing other fluorides and/or active ingredients.