All Times ET
Keywords: Functional data analysis, Historical functional models, Bayesian methods and inference, Wavelet-packets, Environmental exposures
Historical functional linear models (HFLMs) quantify associations between a functional predictor and functional outcome where the predictor is an exposure variable that occurs before, or at least concurrently with, the outcome. Prior work on the HFLM has largely focused on estimation of a surface that represents a time-varying association between the functional outcome and the functional exposure. This existing work has employed frequentist and spline-based estimation methods, with little attention paid to formal inference or adjustment for multiple testing and no approaches that implement wavelet bases. In this work, we propose a new functional regression model that estimates the time-varying, lagged association between a functional outcome and a functional exposure. Building off of recently developed function-on-function regression methods, the model employs a novel use the wavelet-packet decomposition of the exposure and outcome functions that allows us to strictly enforce the temporal ordering of exposure and outcome, which is not possible with existing wavelet-based functional models. Using a fully Bayesian approach, we conduct formal inference on the time-varying lagged association, while adjusting for multiple testing. We investigate the operating characteristics of our wavelet-packet HFLM and compare them to those of two existing estimation procedures in simulation. We also assess several inference techniques and use the model to analyze data on the impact of lagged exposure to particulate matter finer than 2.5µg, or PM2.5, on heart rate variability in a cohort of journeyman boilermakers during the morning of a typical day’s shift.