SC10: Advanced Estimands and Missing Data Imputation in Clinical Trials

This comprehensive short course addresses the critical need for practical implementation guidance following the ICH E9 (R1) addendum on estimands. Despite widespread discussion since its release, many statisticians continue to face challenges in applying the estimands framework and implementing appropriate missing data imputation strategies in real-world clinical trials. This course addresses the gap between theoretical understanding and practical implementation of estimands, providing statisticians with immediately applicable tools and methodologies essential for contemporary clinical trial conduct and regulatory compliance.