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650 – On the Use of Computer-Intensive Methods in Pharmaceutical Research
On the Use of Bayes Techniques to Bridge from an in Vitro System to a Clinical Trial
Sponsor: Biopharmaceutical Section
Keywords: Mimic Technology, Bayesian Modeling, Clinical Trials, In Vitro Study, Pre-Clinical, Vaccine
Ya Meng
Sanofi Pasteur
Camille Salamand
Sanofi Pasteur
Robert D. Small
Sanofi Pasteur
The MIMIC system allows for human experiments to be done in vitro and subjects to be treated with multiple treatments which are not possible in clinical trials. Instead of the typical animal studies, the system can evaluate human immune responses during the pre-clinical period without safety concerns. The objective is to investigate a Bayesian modeling which uses the study information from MIMIC as prior information to the analyses of a clinical trial from the same vaccine candidate. Benefits from MIMIC technology are fully described and results present a potential usage of MIMIC study.