126 – Computational Issues in Survival Models, Biology, and Medicine
Using Simulated Annealing for RNA 3D Structural Comparisons
Ryan Rahrig
Ohio Northern University
In the study of RNA, an important task is finding the structural similarities and differences of two molecules. As the number of 3D structures available has been increasing dramatically in the past decade, it has become important and necessary for automated methods of RNA structural comparison to be developed. Some RNA molecules, such as ribosomal RNA, consists of hundreds or even thousands of nucleotides, making such a task computationally difficult. A method of RNA 3D alignment using a simulated annealing based approach has been developed and is presented. Comparisons of resulting alignments with those produced by other programs are included.
