34 – Recent Advances in Large-Scale Hypothesis Testing
Power and Stability Properties of Resampling-Based Multiple Testing Procedures with Applications to Gene Oncology Studies
Gang Han
Moffitt Cancer Center
Dongmei Li
University of Hawaii at Manoa
Resampling-based multiple testing procedures are widely used in genomic studies to identify differentially expressed genes and to conduct genome-wised association studies (GWAS). However, the power and stability properties of these popular resampling-based multiple testing procedures have not been extensively evaluated yet. Our study focus on investigating the power and stability of several resampling-based multiple testing procedures frequently used in microarray studies through simulations and gene oncology examples and provide some guidance and cautions for researchers using those methods in microarray data analysis.
