JSM2026
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Contributed Papers

Microbiome Analysis and Non-Mendelian Genomic Effects

Sun, Aug 2, 4:00 PM - 5:50 PM Room CC-255 Thomas M. Menino Convention & Exhibition Center
Jason WillwerscheidChair
Section on Statistics in Genomics and Genetics

7 Presentations

A Two-Stage Penalized Kernel Approach for Testing Microbiome–Environment Interaction
4:05 PM - 4:20 PM
Yuzheng Dun
Co-authors: Michael Wu (Fred Hutchinson Cancer Center)
Marker-environment interactionsVariance component testMicrobiomeVariable selectionTwo-stage estimator
An Exponential Scale Mixture Model for Metatranscriptomics Data with Application to Inflammatory Bowel Disease
4:20 PM - 4:35 PM
Hyotae Kim (Duke University)
Co-authors: Li Ma (University of Chicago)
Exponential scale mixture modelingLomax distributionDifferential expression analysisMetatranscriptomics
An Information-Theoretic Framework for Prioritizing Gene-Environment Interactions
4:35 PM - 4:50 PM
Amjila Bam (The Louisiana State University Health Sciences Center (LSUHSC) - New Orleans, LA)
Co-authors: Yawen Hu (School of Medicine, Louisiana State University-Health Sciences Center), Xiao-Cheng Wu (School of Public Health, Louisiana State University-Health Sciences Center), Nubaira Rizvi (LSU-Health New Orleans), Luis Del Valle (School of Medicine, Louisiana State University-Health Sciences Center), Fokhrul Hossain (School of Medicine, Louisiana State University-Health Sciences Center), Jovanny Zabaleta (School of Medicine, Louisiana State University-Health Sciences Center), Augusto Ochoa (School of Medicine, Louisiana State University-Health Sciences Center), Lucio Miele (School of Medicine, Louisiana State University-Health Sciences Center), Edward Trapido (School of Public Health, Louisiana State University-Health Sciences Center), Qingzhao Yu
Mutual InformationHigh-Dimensional DataGene-Environment InteractionInformation TheoryFeature PrioritizationTNBC
Bayesian Inference of Pathogen Genotype-to-fitness Maps from Phylogenies
4:50 PM - 5:05 PM
Shi Cen
Co-authors: Brian Reich (North Carolina State University), David Rasmussen
Multi-type birth-death (MTBD) modelPhylodynamicsPhylogeneticsGenotype-to-fitness mappingBayesian shrinkage
Genomic Imprinting and Maternal Effects Detection Based on the Modified Profile Likelihood Method
5:05 PM - 5:20 PM
Thilini Piyumika Weerasekara
Co-authors: Fangyuan Zhang (Texas Tech University)
case-control studygenomic imprintingmaternal effectsmodified profile likelihoodLagrange multiplier method
Laplacian-Constrained Graphical Models for Compositional Microbial Interaction Networks
5:20 PM - 5:35 PM
Yingshan Qiu (Auburn University)
Co-authors: Yan Li (Auburn University), Elvan Ceyhan (Auburn University)
Laplacian matrixcentered log-ratio transformationGaussian graphical modelmicrobial association network
MAT-GEI: A Fast, Robust and Powerful Method for Multinomial Association Random Effect GxE Test
5:35 PM - 5:50 PM
Mengqi Zhang
Co-authors: Wujuan Zhong (Merck & Co., Inc.), Judong Shen (Merck & Co., Inc.)
GWASGenotype-Environment testMultinomial Association TestCauchy combination
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