Bayesian Hierarchical Models & Methods for Drug Development

Tue, Aug 4, 10:30 AM - 12:20 PM Room CC-254B Thomas M. Menino Convention & Exhibition Center

Ibrahim TurkozChair

Biopharmaceutical Section

7 Presentations

A Meta-analytic Bayesian Hierarchical Variance Model for Powering Frequentist Analysis

10:35 AM - 10:50 AM

Jackson Barth

Co-authors: Ren-Cang Li (University of Texas at Arlington), Xinlei Wang (University of Texas at Arlington)

Sample Size Determination (SSD)Clinical Trials Bayesian Hierarchical Models

A Robust Bayesian Approach to Estimating Treatment Effects in Partially Decentralized Clinical Trial

10:50 AM - 11:05 AM

Peng Yang

Co-authors: Ruitao Lin (University of Texas, MD Anderson Cancer Center), Ying Yuan (University of Texas MD Anderson Cancer Center), Suyu Liu (UT MD Anderson Cancer Center)

Decentralized clinical trials;Machine learning;Mixed-effects model;Covariate adjustment;Randomized clinical trial.

Bayesian Hierarchical change-point regression to evaluate the Antimalarial Activity

11:05 AM - 11:20 AM

Nairita Ghosal (Merck & Co., Inc.)

Co-authors: Avizit Chandra Adhikary

Changepoint regression Parasite Clearance Malaria

Bayesian Hierarchical Emax vs MCP-Mod for Phase II dose-ranging Clinical Trials

11:20 AM - 11:35 AM

Naima Alam (University of Kansas Medical Center)

Co-authors: Byron Gajewski (University of Kansas Medical Center)

Bayesian models MCP-Mod Hierarchical models Dose-ranging Minimum effective dose

Bayesian Variable Selection via Adaptive Posterior-Informed Shrinkage Prior

11:35 AM - 11:50 AM

Yaoyuan Vincent Tan (Vertex Pharmaceuticals)

Co-authors: Lingxuan Kong (University of Michigan, Ann Arbor), Chenkun Wang (Vertex Pharmaceuticals Inc), Yumin Zhang (Vertex Pharmaceuticals)

Bayesian hierarchical modeling Bayesian variable selection adaptive data borrowing shrinkage priors CIT06 CIT07

Beta and Truncated-Normal Bayesian Mixed Models for Predicting Longitudinal Clinical Scores.

11:50 AM - 12:05 PM

Joel Correa da Rosa (Icahn Mount Sinai School of Medicine)

Co-authors: Akbobek Amangeldiyeva (Icahn Mount Sinai School of Medicine)

Clinical Trials Bayesian Inference Counterfactural prediction Truncated Normal Beta distribution Mixed Models

Bivariate Bayesian quantitative decision making in rare disease drug development

12:05 PM - 12:20 PM

Yusuke Yamaguchi (Astellas Pharma Global Development, Inc.)

Rare disease drug development Bayesian approach Multiple endpoint Decision-making Clinical trial