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Contributed Papers

Biomarkers, Precision Medicine & Individualized Treatment Rules

Mon, Aug 3, 10:30 AM - 12:20 PM Room CC-208 Thomas M. Menino Convention & Exhibition Center

Erica TongChair

Biopharmaceutical Section

7 Presentations

A Transcriptome Signature Reversion Score for Evaluating Bi-Specific Drug Effects in Immunology

10:35 AM - 10:50 AM

Kyungin Kim (Sanofi)

Transcriptome Signature Reversion Gene expression Pharmacodynamic metric

Bayesian Hierarchical Modeling for Optimal Biomarker Cut-point Determination

10:50 AM - 11:05 AM

Co-authors: Liying Chen, Chunxiao Wang (Eli Lilly and Company), Sameera Wijayawardana (Eli Lilly)

Bayesian Hierarchical Model Clinical Trial Subgroup Identification

Integrated multi-panel biomarker analysis for identification of mechanisms of biological actions

11:05 AM - 11:20 AM

Co-authors: Yichen Jia (Sanofi), Donghui Zhang (Sanofi)

biomarkers exploratory assay integrated analysis

Log It or Leave It: Decision Framework for Transforming Biomarker Data in Clinical Trials

11:20 AM - 11:35 AM

Ann Marie Weideman (Eli Lilly and Company)

Co-authors: Shaolei Ma (Eli Lilly and Company), Qin Huang (Eli Lilly and Company), Amir Nikooie (Eli Lilly and Company), Yongming Qu (Eli Lilly and Company)

Biomarkers Log transformation Clinical trials Cardiometabolic health Residual diagnostics Model diagnostics

MatchBART-ITR: A Matching-Based Bayesian Framework for Individualized Treatment Rules

11:35 AM - 11:50 AM

Zhizhen Zhao (The Ohio State University)

Co-authors: Bo Lu (The Ohio State University), Xinyi Xu

Individualized treatment rules Matching designs Bayesian additive regression tree Uncertainty-based decision rules

Measuring the individualization potential of medical individualized treatment rules

11:50 AM - 12:05 PM

Francisco Diaz (University of Kansas Medical Center)

Latent variables Personalized medicine Random effects Structural equation models Treatment-covariate interaction Medical decision making

Pathway Network: Novel Penalty Strategy for Biomarker Detection in High-Dimensional Mediation Models

12:05 PM - 12:20 PM

Pei-Shan Yen (University of Illinois at Chicago)

Co-authors: Leon Zhou (University of Illinois at Chicago), Soumya Sahu, Debarghya Nandi (University of Illinois at Chicago), Dulal Bhaumik (University of Illinois At Chicago)

Biomarker Detection Pathway LASSO Regularization Mediation Functional Connectivity

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