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Contributed Papers

Bayesian Methods for Information Borrowing — Power Priors & Mixture Priors

Tue, Aug 4, 2:00 PM - 3:50 PM Room CC-206B Thomas M. Menino Convention & Exhibition Center

Zhangchen ZhaoChair

Biopharmaceutical Section

6 Presentations

An Adaptive Weight in the Robust Meta-Analytic Predictive Prior for External Information Borrowing

2:05 PM - 2:20 PM

Ruoxuan Xiang (U.S. FDA)

Co-authors: John Scott (FDA)

Clinical trials Bayesian Information Borrowing prior elicitation

ANPP: the Adapted Normalized Power Prior for Borrowing Information from Multiple Historical Datasets

2:20 PM - 2:35 PM

Angie Shen (Merck & Co.)

Co-authors: Matthew Psioda (GSK), Luiz Carvalho (Getulio Vargas Foundation), Joseph Ibrahim (University of North Carolina)

Clinical Trials External Control Bayesian Analysis Power Prior

MLPP: Maximum Likelihood-Based Power Prior for Dynamic Information Borrowing

2:35 PM - 2:50 PM

Yiyao Shi (University of California, Irvine)

Co-authors: Anran Wang (Merck & Co., Inc.), Shuyan Wan (Merck & Co., Inc.), Qing Li (Merck & Co., Inc.), Siyi Liu (Merck & Co., Inc.), Dabao Zhang (University of California, Irvine), Weining Shen (University of California, Irvine)

Bayesian Clinical Trials Dynamic Borrowing Power Prior Information Borrowing Consistency External Evidence Hybrid Control

Conjugate Representation of Power Priors for Efficient Bayesian Analysis of Normal Data

2:50 PM - 3:05 PM

Co-authors: Yusuke Yamaguchi (Astellas Pharma Global Development, Inc.), Gosuke Homma (Astellas Pharma Inc), Kazushi Maruo (University of Tsukuba), Kentaro Takeda (Astellas Pharma Global Development, Inc.)

power priors Bayesian analysis historical data conjugate priors clinical trials R package

Calibirated Power Prior for a Randomized, Double-Blinded and Non-inferiority Study

3:05 PM - 3:20 PM

Xiaoqiang Xue (Syneos Health)

Co-authors: Zejiang Yang (Syneos Health)

Bayesian Power Prior Time to MACE Hazard ratio,Cox proportional model

Bayesian Dynamic Borrowing for Multi-Endpoint Survival Trials Using Deep Neural Network

3:20 PM - 3:35 PM

Yunyi Liu (UC San Diego, Department of Family Medicine & Public Health)

Co-authors: Sonia Jain (University of California, San Diego)

Bayesian dynamic borrowing Deep neural networks Historical controls Survival analysis

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