SMART-er Clinical Trials: Improvements in Sequential Multiple Assignment Randomized Trial Design, Analysis, and Reporting

Sun, Aug 2, 2:00 PM - 3:50 PM Room CC-253B Thomas M. Menino Convention & Exhibition Center

Cole ManschotOrganizerCole ManschotChair

Biopharmaceutical Section co: Biometrics Sectionco: ENAR Applied

5 Presentations

Interim Analysis in Sequential Multiple Assignment Randomized Trials for Survival Outcomes

2:05 PM - 2:25 PM

Abdus Wahed (University of Rochester)

Dynamic Treatment Regimes Efficacy Boundaries Interim Monitoring Inverse Probability Weighting Log-rank Statistics Trial Efficiency

SMART Designer: An Interactive Tool for Constructing and Evaluating SMART Designs

2:25 PM - 2:45 PM

Yujie Zhao (Merck & Co., Inc.)

Co-authors: Xinyu Zhang (University of North Carolina at Chapel Hill), Yujie Zhao (Merck & Co., Inc.), Zheng Wang (Merck & Co., Inc., Rahway, NJ, USA), Liyi Jia (Merck & Co., Inc.), Keaven Anderson (Merck & Co., Inc.)

SMART Time-to-Event Oncology Perioperative Trials

Pareto SMARTs for Balancing In-Trial and Out-of-Trial Patient Outcomes

2:45 PM - 3:05 PM

Eric Laber

Sequential design Pareto efficiency

An R package for the Design and Analysis of Sequential Multiple Assignment Randomized Trials

3:05 PM - 3:25 PM

Gabriela Piasecki (Merck & Co., Inc.)

R package Sequential multiple assignment randomized trials Adaptive design Hypothesis testing

Inference for General Outcomes in Sequential Multiple Assignment Randomized Trials with Interim Monitoring

3:25 PM - 3:45 PM

Nathan Provost

Dynamic treatment regimes Generalized estimating equations Interim monitoring Missing data Robust inference SMARTs