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Contributed Papers

Pioneering Bayesian Dynamic Borrowing: Enhancing Clinical Trial Design and Analysis

Mon, Aug 4, 2:00 PM - 3:50 PM Room CC-208A Music City Center

Zizhong TianChair

Biopharmaceutical Section

6 Presentations

A Bayesian hybrid Dynamic Borrowing Framework Incorporating Covariates

2:05 PM - 2:20 PM

Co-authors: Zhaohua Lu, Yiyuan Huang, Zhaohua Lu, Philip He (Daiichi Sankyo Inc.)

Bayesian hybrid design dynamic borrowing nonconcurrent control power prior propensity score

Boosting the Power of Hybrid Design When Crossover Occurred in Historical Control

2:20 PM - 2:35 PM

Co-authors: Leiwen Gao (Amgen Inc.), Leiwen Gao (Amgen Inc.), Qixiang Xu (Department of Biostatistics, Yale University), Qing Liu (Amgen Inc.)

Hybrid design RCT Historical control Crossover Bayesian dynamic borrowing Commensurate prior

WITHDRAWN Building a Hybrid External Control Arm Using a Fusion of Bayesian Borrowing and Causal Inference

2:35 PM - 2:50 PM

Co-authors: Ilana Trumble (GSK), Antara Majumdar (GSK)

hybrid external control arms (HECAs)Bayesian borrowing Causal inference inverse probability of treatment weighting (IPTWs)robust mixture priors clinical trial design

Concordance-based prior to dynamically borrow information for pediatric extrapolation

2:50 PM - 3:05 PM

Co-authors: Weiyu Zhou, Siyu Zhang (Vertex Pharmaceuticals), Weiyu Zhou, Pengyu Liu, Fengjuan Xuan (Vertex)

Bayesian data borrowing Pediatric extrapolation Clinical trial

Matching-assisted power prior for incorporating real-world data in randomized clinical trial

3:05 PM - 3:20 PM

Co-authors: Ruoyuan Qian (The Ohio State University), Ruoyuan Qian (The Ohio State University), Biqing Yang (The Ohio State University), Xinyi Xu, Bo Lu (The Ohio State University)

Bayesian dynamic borrowing power prior template matching propensity score real-world data

Propensity score stratified MAP prior and posterior inference for incorporating external data

3:20 PM - 3:35 PM

Co-authors: Angela Zhu (Boehringer Ingelheim), Dooti Roy (Boehringer Ingelheim Pharmaceuticals, Inc.), Angela Zhu (Boehringer Ingelheim), Zheng Zhu, Martin Oliver Sailer (Boehringer Ingelheim)

propensity score Bayesian borrowing external controls heterogeneity

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