Invited Paper Session

Emerging Statistical/Computational Methods for Genomic Data Science in the Era of Diverse Biobanks

Wed, Aug 6, 8:30 AM - 10:20 AM Room CC-103B Music City Center

Xihao LiOrganizerXihao LiChair

Section on Statistics in Genomics and Genetics Applied

4 Presentations

Testing a large number of composite null hypotheses for mediation, pleiotropy, and replication analyses in genome-wide studies

8:35 AM - 9:00 AM

Ryan Sun (University of Texas, MD Anderson Cancer Center)

Co-authors: Ryan Sun (University of Texas, MD Anderson Cancer Center), Zachary McCaw (Harvard School of Public Health), Xihong Lin (Harvard T.H. Chan School of Public Health)

Composite null Empirical Bayes Mediation analysis Pleiotropy Replication analysis Genome-wide association study

Using large language models for rare variant association testing in large-scale biobanks

9:00 AM - 9:25 AM

Joelle Mbatchou

Co-authors: Christopher Gillies (Regeneron Genetics Center), Andrey Ziyatdinov (Regeneron Genetics Center), The Regeneron Genetics Center (Regeneron Genetics Center), Maya Ghoussaini (Regeneron Genetics Center), Jonathan Marchini (Regeneron Genetics Center)

PresentationCC

9:25 AM - 9:50 AM

Nilanjan Chatterjee

Co-authors: Wenxuan Lu (Bloomberg School of Public Health, Johns Hopkins University), Yuzheng Dun, Ruzhang Zhao (Johns Hopkins University)

Integrating Common and Rare Variants Improves Polygenic Risk Prediction Across Diverse Populations

9:50 AM - 10:15 AM

Haoyu Zhang (National Cancer Institute)

Co-authors: Peter Kraft (National Cancer Institute), Wendy Wong (National Cancer Institute), Jacob Williams, Tony Chen (Harvard University), Xing Hua, Kai Yu, Xihao Li (University of North Carolina at Chapel Hill), Haoyu Zhang (National Cancer Institute)